COAGULATION ASSAYS AND AT-III ON LEVONORGESTREL IMPLANT ACCEPTORS

Background: Indonesia is the fourth most populous country in the world, so the government has focused Family Planning Program using contraception. Implants and IUDs are two most effective reversible contraceptive methods and often used in Indonesia. Implant releases progestin, with most common reported side effect of abnormal bleeding. Specically for levonorgestrel implants, changes in menstrual intervals, duration, volume of menstrual ow can occur. Progestins are believed to cause changes in platelet and blood vessel, leading to hypercoagulability state, which can be assessed through coagulation assays (PT, TT, aPTT) and level of AT-III. Objective: This aims to determine the differences in coagulation assays and AT-III levels between levonorgestrel implant versus IUD acceptors. Methods: This study was an observational analytic study with retrospective cross-sectional design. The population were case population (levonorgestrel implant acceptors) and control population (IUD). A total of 74 respondents were chosen by consecutive sampling. Characteristics data were obtained by interview, anthropometric measurements, and medical records; PT, TT, aPTT, and AT-III data were obtained from blood samples by ELISA method. An independent T-test was used to analyze the data. Results: Mean PT was the same for implant and IUD users, 13.11 seconds (SD=0.81 seconds) (p=0.1,000). Mean TT of implant users was 14.78 seconds (SD=1.18 seconds) and IUD 14.58 seconds. (SD=1.18 seconds) (p=0.75). Mean aPTT for implant users was 30.22 seconds (SD=4.65 seconds) and IUD 30.55 seconds (SD=2.79 seconds) (p=0.200). Mean of ATIII in implant users was 92.18% (SD=9.72%) and IUD 84.79% (SD=14.74%) (p=0.250). Conclusion: No signicant mean differences for PT, TT, aPTT, and AT-III between groups of levonorgestrel implant and IUD acceptors (p value> 0.05).