Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
A concise review on analytical profile of Vigabatrin
View through CrossRef
Vigabatrin (VGB) is a drug of Anticonvulsant class. It works by decreasing abnormal electrical activity in the brain. It inhibits the GABA-degrading enzyme i.e. GABA transaminase, it increases the GABA concentrations in the brain. Vigabatrin is used for the treatment of refractory complex partial seizures in adults and also used for children 2 years of age and older and infantile spasms in children. Vigabatrin was approved for anticonvulsant medication by USFDA on August 21, 2009. Therefore, in the present review article, we have enlisted different analytical method such as Ultraviolet (UV) visible spectroscopy, High-performance liquid chromatography (HPLC), Ultra-performance liquid chromatography (UPLC) and Gas Chromatography for both qualitative and quantitative analysis of VGB in pharmaceutical and biological. In the future, this review article will assist researchers regarding the development of a new analytical method for VGB.
Title: A concise review on analytical profile of Vigabatrin
Description:
Vigabatrin (VGB) is a drug of Anticonvulsant class.
It works by decreasing abnormal electrical activity in the brain.
It inhibits the GABA-degrading enzyme i.
e.
GABA transaminase, it increases the GABA concentrations in the brain.
Vigabatrin is used for the treatment of refractory complex partial seizures in adults and also used for children 2 years of age and older and infantile spasms in children.
Vigabatrin was approved for anticonvulsant medication by USFDA on August 21, 2009.
Therefore, in the present review article, we have enlisted different analytical method such as Ultraviolet (UV) visible spectroscopy, High-performance liquid chromatography (HPLC), Ultra-performance liquid chromatography (UPLC) and Gas Chromatography for both qualitative and quantitative analysis of VGB in pharmaceutical and biological.
In the future, this review article will assist researchers regarding the development of a new analytical method for VGB.
Related Results
Evidence for both in vivo and in vitro interaction between vigabatrin and alanine transaminase
Evidence for both in vivo and in vitro interaction between vigabatrin and alanine transaminase
Aims Decreases in plasma alanine transaminase (ALA‐T) activity of 20–100% have been reported following the use of vigabatrin (Sabril) in patients with uncontrolled epilepsy. This e...
Infantile Spasms and Epilepsy Currents
Infantile Spasms and Epilepsy Currents
The United Kingdom Infantile Spasms Study Comparing Vigabatrin with Prednisolone or Tetracosactide at 14 Days: A Multicentre, Randomised Controlled Trial Lux AL, Edwards SW, Hanco...
Vigabatrin versus ACTH in the treatment of infantile spasms
Vigabatrin versus ACTH in the treatment of infantile spasms
OBJECTIVE: To compare adrenocorticotropic hormone with vigabatrin as a single mono-therapy for infantile spasms. We studied hospitalization time, clinical response, whether complet...
Vigabatrin: Lessons Learned From the United States Experience
Vigabatrin: Lessons Learned From the United States Experience
Abstract:
Vigabatrin was introduced as an antiseizure medication in the United Kingdom in 1989 and was extensively used until 1997 when concerns arose regarding periphera...
Evaluating the Science to Inform the Physical Activity Guidelines for Americans Midcourse Report
Evaluating the Science to Inform the Physical Activity Guidelines for Americans Midcourse Report
Abstract
The Physical Activity Guidelines for Americans (Guidelines) advises older adults to be as active as possible. Yet, despite the well documented benefits of physical activi...
Clinical pharmacology of vigabatrin.
Clinical pharmacology of vigabatrin.
1. Upon oral administration vigabatrin is rapidly absorbed. Plasma elimination half‐life ranges between 5 and 7 h in normal volunteers. Vigabatrin is eliminated primarily via the k...
Effects of Vigabatrin (γ‐vinyl GAB A) on Neuro transmission‐Related Amino Acids and on GAB A nd Benzodiazepine Receptor Binding in Rats
Effects of Vigabatrin (γ‐vinyl GAB A) on Neuro transmission‐Related Amino Acids and on GAB A nd Benzodiazepine Receptor Binding in Rats
Summary: The effect of 12‐day intraperitoneal i.p. administration of vigabatrin (GVG, γ‐vinyl GAB A) to rats on the neurotransmission‐related amino acids in various brain regions ...
Vigabatrin: What Went Wrong with the Anti-Epileptic Wonder Drug?
Vigabatrin: What Went Wrong with the Anti-Epileptic Wonder Drug?
As vigabatrin was being used, it became associated with retinal toxicity causing constriction of the visual field. These visual field deficits reported in association with vigabatr...