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Vigabatrin: What Went Wrong with the Anti-Epileptic Wonder Drug?
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As vigabatrin was being used, it became associated with retinal toxicity causing constriction of the visual field. These visual field deficits reported in association with vigabatrin prompted a review of its place in the management of epilepsy, halting its use. However, in 2009, it was later approved by the United States Food and Drug Administration (FDA) for use as monotherapy in the treatment of infantile spasms in patients aged 1 month to 2 years, based on the benefits of the treatment outweighing the risks.
Title: Vigabatrin: What Went Wrong with the Anti-Epileptic Wonder Drug?
Description:
As vigabatrin was being used, it became associated with retinal toxicity causing constriction of the visual field.
These visual field deficits reported in association with vigabatrin prompted a review of its place in the management of epilepsy, halting its use.
However, in 2009, it was later approved by the United States Food and Drug Administration (FDA) for use as monotherapy in the treatment of infantile spasms in patients aged 1 month to 2 years, based on the benefits of the treatment outweighing the risks.
Related Results
Evidence for both in vivo and in vitro interaction between vigabatrin and alanine transaminase
Evidence for both in vivo and in vitro interaction between vigabatrin and alanine transaminase
Aims Decreases in plasma alanine transaminase (ALA‐T) activity of 20–100% have been reported following the use of vigabatrin (Sabril) in patients with uncontrolled epilepsy. This e...
Infantile Spasms and Epilepsy Currents
Infantile Spasms and Epilepsy Currents
The United Kingdom Infantile Spasms Study Comparing Vigabatrin with Prednisolone or Tetracosactide at 14 Days: A Multicentre, Randomised Controlled Trial Lux AL, Edwards SW, Hanco...
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Spreading Depolarizations (SDs) are often associated with epileptic discharges. While SDs are traditionally thought contributing to the postictal depressio...
Characteristics of malignant brain tumor‐associated epileptic spasms
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Abstract
Objective
Spreading depolarizations (SDs) are often associated with epileptic discharges. Although SDs are tradi...
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Abstract
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BACKGROUND
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