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Synthesis, characterization and antioxidant activity of sulfonyl-1H-1,2,3-triazoles
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3-methoxy-4-((1-tosyl-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde (3), 4-((1-(ethylsulfonyl)-1H-1,2,3-triazol-4-yl) methoxy) benzaldehyde (6), 4-((1-((4-chloro phenyl) sulfonyl)-1H-1,2,3-triazol-4-yl) methoxy) benzaldehyde (9), 4-((4-((1-(ethylsulfonyl)-1H-1,2,3-triazol-4-yl) methoxy) benzylidene) amino)phenol (7), 4-((4-((1-((4-chlorophenyl) sulfonyl)-1H-1,2,3-triazol-4-yl) methoxy) benzylidene) amino) phenol (10), 4-((4-((1-tosyl-1H-1,2,3-triazol-4-yl) methoxy) benzylidene)amino) phenol (12) were synthesized. The compounds were characterized by FTIR, 1H-NMR and 13C-NMR spectroscopic methods. The antioxidant properties of the compounds were evaluated using two widely accepted methodologies assays (DPPH and FRAP). Compounds 7 and 10 emerged as the most potent antioxidant candidates, displaying the strongest effects in both assays.
Title: Synthesis, characterization and antioxidant activity of sulfonyl-1H-1,2,3-triazoles
Description:
3-methoxy-4-((1-tosyl-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde (3), 4-((1-(ethylsulfonyl)-1H-1,2,3-triazol-4-yl) methoxy) benzaldehyde (6), 4-((1-((4-chloro phenyl) sulfonyl)-1H-1,2,3-triazol-4-yl) methoxy) benzaldehyde (9), 4-((4-((1-(ethylsulfonyl)-1H-1,2,3-triazol-4-yl) methoxy) benzylidene) amino)phenol (7), 4-((4-((1-((4-chlorophenyl) sulfonyl)-1H-1,2,3-triazol-4-yl) methoxy) benzylidene) amino) phenol (10), 4-((4-((1-tosyl-1H-1,2,3-triazol-4-yl) methoxy) benzylidene)amino) phenol (12) were synthesized.
The compounds were characterized by FTIR, 1H-NMR and 13C-NMR spectroscopic methods.
The antioxidant properties of the compounds were evaluated using two widely accepted methodologies assays (DPPH and FRAP).
Compounds 7 and 10 emerged as the most potent antioxidant candidates, displaying the strongest effects in both assays.
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