Recent achievements in studying the reactivity of 1,2,4-triazole-3-thione derivatives (literature review)

Compounds with open thiogroup have high indicators of antioxidant, antiradical activity and positive impact on the overall condition and biochemical processes in patients who received high doses of radiation. Some authors compare synthesized 3-thio-1,2,4-triazoles with biogenic amino acids such as cysteine, which also has free SH-group in its structure. But in recent years, very few studies summarize the chemical transformations involving appointed class of compounds that was the main purpose of our work. The materials of research were scientific information sources on the synthesis and pharmacological activity of a series of 1,2,4-triazoles-3-thiones and 4-amino-3-thio-1,2,4-triazoles. We used content analysis, systematic and comparative methods and also the generalization of results. Analyzed scientific resources, which are devoted to the synthesis and study of pharmacological activity in a series of 1,2,4-triazoles-3-thiones and 4-amino-3-thio-1,2,4-triazoles show new possibilities and opportunities that are provided by synthesized 1,2,4-triazole-3-tiones, on the example of 5-R-5R1-3-heteryltio-1,2,4-triazoles.