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Effect of cerium dioxide nanoparticles on the expression of selected growth and transcription factors in human astrocytes
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AbstractThis study was undertaken to examine the effect of cerium dioxide nanoparticles on the expression levels of genes, encoded transcription and growth factors, which are important for control of cell proliferation and survival in human astrocytes. Exposure of astrocytes with cerium dioxide nanoparticles (0.17 and 0.34 mg/ml of medium) during 20 h significantly decreases the expression level of transcription factors TBX3, E2F8 and FOXF1 mRNAs, being stronger for higher doses of nanoparticles. Moreover, the expression levels of IGFBP1 and IGFBP2 as well as LIF mRNA also significantly decreased in astrocytes after treatment with cerium dioxide nanoparticles. It is possible that the observed changes in the expression profile of the studied genes in astrocytes treated with cerium dioxide nanoparticles are associated with its toxic effect mediated by endoplasmic reticulum stress sensor‐signaling systems in part through the bifunctional membrane enzyme ERN1. Thus, cerium dioxide nanoparticles have a significant effect on important regulatory mechanisms, which control cell proliferation and survival in human astrocytes.
Title: Effect of cerium dioxide nanoparticles on the expression of selected growth and transcription factors in human astrocytes
Description:
AbstractThis study was undertaken to examine the effect of cerium dioxide nanoparticles on the expression levels of genes, encoded transcription and growth factors, which are important for control of cell proliferation and survival in human astrocytes.
Exposure of astrocytes with cerium dioxide nanoparticles (0.
17 and 0.
34 mg/ml of medium) during 20 h significantly decreases the expression level of transcription factors TBX3, E2F8 and FOXF1 mRNAs, being stronger for higher doses of nanoparticles.
Moreover, the expression levels of IGFBP1 and IGFBP2 as well as LIF mRNA also significantly decreased in astrocytes after treatment with cerium dioxide nanoparticles.
It is possible that the observed changes in the expression profile of the studied genes in astrocytes treated with cerium dioxide nanoparticles are associated with its toxic effect mediated by endoplasmic reticulum stress sensor‐signaling systems in part through the bifunctional membrane enzyme ERN1.
Thus, cerium dioxide nanoparticles have a significant effect on important regulatory mechanisms, which control cell proliferation and survival in human astrocytes.
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