Systemic inflammation response index (SIRI) predicts mortality and cardiovascular events in maintenance hemodialysis patients: A correlational study

Maintenance hemodialysis (MHD) patients generally experience a state of micro-inflammation, which increases the risk of all-cause mortality and cardiovascular events (CVEs). The systemic inflammatory response index (SIRI) is a novel inflammatory marker that reflects the body’s inflammatory state. Research has shown that SIRI not only serves as a prognostic indicator for many cancer-related diseases but also as a predictor for the occurrence of cardiovascular and cerebrovascular diseases. Currently, there is a paucity of research investigating the correlation between SIRI and all-cause mortality or the incidence of CVEs in patients undergoing MHD. This study is a retrospective cohort study, which collected 275 newly admitted MHD patients. The study population was divided into 2 groups based on the median value of SIRI. Kaplan–Meier cumulative incidence curves, multivariable logistic regression analysis, and competing risk model analysis were used to investigate the correlation between SIRI and all-cause mortality and CVE in MHD patients. Of all the patients, 275 cases of newly admitted MHD patients were recorded. Restricted cubic spline analysis revealed a linear association between the SIRI and all-cause morality as well as CVE. The Kaplan–Meier curves demonstrated differences in both all-cause mortality and CVE between the 2 groups. The competitive risk model suggested a significant difference in the cumulative incidence of all-cause mortality and CVE between the 2 groups. Compared to low SIRI group, adjusted Cox model showed that high SIRI group was associated with increased risk of all-cause mortality and CVE (all-cause mortality: odds ratio, 3.652; 95% confidence interval 1.812–7.363; P  < .001; new-onset CVEs: odds ratio, 2.224; 95% confidence interval 1.191–4.155; P  = .012). High SIRI levels are independent risk factors for all-cause mortality and CVEs in MHD patients.