Exploring the trend of Schizophrenia at Hiwot Fana specialized university referral hospital, Eastern, Ethiopia (2016–2020): A 5-year retrospective analysis

Schizophrenia is one of the most troublesome psychiatric problems requiring long-term antipsychotic treatments. There is a scarcity of data regarding its overtime trend in Ethiopia. Objective: To explore the 5-year trend of schizophrenia at Hiwot Fana Specialized University Referral Hospital, Eastern Ethiopia. Methods: A hospital-based retrospective record review was conducted at Hiwot Fana Specialized University Referral Hospital, Eastern Ethiopia. Data were obtained from medical records of all registered psychiatric patients in the psychiatric follow-up clinic over 5 years from 2016 to 2020. An Extended Mantel-Haenszel chi-square test for the linear trend was used to examine the trend over the 5-year period. Results: Over the 5-year period stated (2016–2020), a total of 29,184 psychiatric patients were registered at the Hospital from which 18,598 (63.73 % (95% confidence interval: 0.63–0.64) were schizophrenia confirmed cases. Of the 18,598 patients, 15,362 (82.60%) were males and 7,625 (41%) were in 25–34 years of age category. It was revealed that the trend of newly diagnosed patients with schizophrenia increased from (0.44 (95% CI (0.39–0.47) in 2016 to 0.47(95% confidence interval: (0.44–0.49) in 2020 (χ 2  = 3.87; p = 0.049). Those chewing Khat were disproportionately affected accounting for about half of the schizophrenia total cases reported. Conclusion: The magnitude of patients with schizophrenia being treated at the hospital increased over the 5 years studied. Tailored preventive and treatment interventions are needed to mitigate the problem. Community and institution-based customized interventions can be designed using the existing health system platforms.