Kajian Literatur Microneedle Patch dalam Menangani Jerawat (Acne vulgaris)

Abstract. Acne (Acne vulgaris) is a chronic inflammatory skin disease commonly occurring in adolescents and adults. Acne is influenced by excessive sebum production, hyperkeratinization, bacterial colonization and inflammatory reactions. Microneedle patch is an innovative microneedle-based transdermal system that delivers active ingredients to the skin effectively without pain. The purpose of this study was to examine the active ingredients, types of microneedles, the effectiveness and safety of microneedle patches in treating acne. This study was conducted using the Systematic Literature Review (SLR) method on research articles from scientific databases from 2015–2025. The results of the study showed that the active ingredients used were Matrine, Salicylic Acid, Azelaic Acid, and Triamcinolone Acetonide showed high antibacterial activity. Microneedle patches, especially the dissolving type of microneedle, can dissolve in the skin without causing pain. Microneedle patches effectively damage the structure of bacterial cells and reduce bacterial viability, reduce IL-1β, and accelerate acne healing in 4–6 days. Microneedle patches are declared safe because they do not cause irritation, hemolysis <5%, and are free from toxic effects. Thus, microneedle patches are effective and safe to use as acne therapy. Abstrak. Jerawat (Acne vulgaris) merupakan penyakit kulit inflamasi kronis umumnya terjadi pada remaja dan dewasa. Jerawat dipengaruhi oleh produksi sebum berlebih, hiperkeratinisasi, kolonisasi bakteri dan reaksi inflamasi. Microneedle patch merupakan inovasi sistem transdermal berbasis jarum mikro yang menghantarkan bahan aktif ke kulit secara efektif tanpa rasa sakit. Tujuan dari penelitian ini untuk mengkaji bahan aktif, jenis microneedle, efektivitas dan keamanan dari microneedle patch dalam menangani jerawat. Kajian ini dilakukan dengan metode Systematic Literature Review (SLR) terhadap artikel penelitian dari database ilmiah tahun 2015–2025. Hasil kajian menunjukkan bahan aktif yang digunakan adalah Matrine, Salicylic Acid, Azelaic Acid, dan Triamcinolone Acetonide menunjukkan aktivitas antibakteri tinggi. Microneedle patch khususnya jenis dissolving microneedle dapat larut dalam kulit tanpa menimbulkan rasa sakit. Microneedle patch efektif merusak struktur sel bakteri dan menurunkan viabilitas bakteri, menurunkan IL-1β, serta mempercepat penyembuhan jerawat dalam 4–6 hari. Microneedle patch dinyatakan aman karena tidak menimbulkan iritasi, hemolisis <5%, dan bebas efek toksik. Dengan demikian, microneedle patch efektif dan aman digunakan sebagai terapi jerawat.