Search engine for discovering works of Art, research articles, and books related to Art and Culture
ShareThis
Javascript must be enabled to continue!

A Scoping Review of Unani Medicinal Herbs Used to Treat Acne Vulgaris

View through CrossRef
Acne vulgaris (Buthūr Labaniyya) is among the most prevalent dermatological conditions worldwide, often leading to low self-esteem and negatively impacting the quality of life. Conventional treatments have been widely used, but prolonged use has caused the emergence of resistance against acne-causing pathogens. This paper explores the therapeutic potential of medicinal herbs mentioned in classical Unani literature approach to treating acne. A comprehensive detailed search was conducted using classical Unani texts and modern scientific databases such as PubMed and Google Scholar to identify Unani medicinal herbs with anti-acne properties. Various clinical studies have reported that the selected herbal drugs exhibit significant anti-acne effects, though further research is needed to determine the specific chemical constituents responsible for these properties. Among the plant parts, roots were the most frequently mentioned for their therapeutic benefits. 1. Abiya, S.E. et al. (2018) “Antimicrobial activity of three medicinal plants against acne-inducing bacteria Propionibacterium acnes,” Brazilian Journal of Biological Sciences, 5(10), p. e 315. Available at: https://doi.org/10.21472/bjbs.051008. 2. Ahmad, F. and Ahmad, H. (2012) “Antibacterial Activity of Raphanus Sativus Linn,” Seed Extract... GJMR, 12, pp. 25–33. 3. Al-Hindawi, M.K., Al-Deen, I.H., Nabi, M.H. and Ismail, M.A., 1989. Anti-inflammatory activity of some Iraqi plants using intact rats. Journal of Ethnopharmacology, 26, pp.163–168. 4. Anṭākī, D., 2010. Tadhkira Ūlī al-Albāb. New Delhi, India: Central Council for Research in Unani Medicine (CCRUM), Ministry of Health & Family Welfare, p. 87. 5. Arzani, H.M.A., 2016. Ṭibb-I Akbar. Translated by Hussain, H.M. Deoband, India: Faisal Publications, pp. 697, 722. 6. Baghdādī, I.H., 2007. Kitāb al-Mukhtārāt fiʼl Ṭibb. Vol. 4. New Delhi, India: Central Council for Research in Unani Medicine (CCRUM), Department of AYUSH, Ministry of Health & Family Welfare, pp. 188–189. 7. Bashir, A. et al. (2011) “Comparative study of antimicrobial activities of Aloe vera extracts and antibiotics against isolates from skin infections,” African Journal of Biotechnology, 10, pp. 3835–3840. 8. Batubara, I. and Mitsunaga, T. (2013) “Use of Indonesian medicinal plants products against acne,” Reviews in agricultural science, 1(0), pp. 11–30. Available at: https://doi.org/10.7831/ras.1.11. 9. Campisanoa, O.L. et al. (2014) “Interkingdom transfer of the acne-causing agent, propionibacterium acnes, from human to grapevine,” Mol Biol Evol, 31, pp. 1059–1065. 10. Chaudhary, S. et al. (2013) “The In vitro anti-acne activity of two unani drugs,” Ancient science of life, 33(1), p. 35. Available at: https://doi.org/10.4103/0257-7941.134594. 11. Chen, C.-H. et al. (2017) “Isoflavones and anti-inflammatory constituents from the fruits of Psoralea corylifolia,” Phytochemistry, 143, pp. 186–193. Available at: . 12. Dubey, D., Prashant, K. and Jain, S. (2009) “In-vitro antioxidant activity of the ethyl acetate extract of gum guggul (Commiphora mukul),” Proceedings of the Biological Forum-An Int J, pp. 32–35. 13. Działo, M. et al.(2016) “The potential of plant phenolics in prevention and therapy of skin disorders,” International journal of molecular sciences, 17(2), p. 160. Available at: https://doi.org/10.3390/ ijms17020160. 14. Fajryana, A. et al. (2022) “Antibacterial activity of garlic extract (Allium sativum) using fermentation and non-fermentation towards Propionibacterium acne,” IOP conference series. Earth and environmental science, 1083(1), p. 012070. Available at: https://doi. org/10.1088/1755-1315/1083/1/012070. 15. Fitzpatrick, T.B. et al. (2001) “Colour Atlas and Synopsis of Clinical Dermatology, United States of America: Mc-Graw Hill Companies,” pp. 51–52. 16. Ganaie, A.A., Mishra, R.P. and Allaie, A.H. (2018) “Antioxidant activity of some extracts of Iris ensata,” Journal of Pharmacognosy and Phytochemistry, 7, pp. 230–235. 17. Geelani, G., 1996. Makhzane Hikmat. Vol. 2. Lahore: Basheer and Sons, pp.689–691. 18. Ghosh, V.K. et al. (2011) “Different approaches of alternative medicines in acne vulgaris treatment,” Oriental pharmacy and experimental medicine, 11(1), pp. 1–9. Available at: https://doi. org/10.1007/s13596-011-0006-6. 19. Giri, K.R. (2016) “Comparative study of anti-inflammatory activity of Withania somnifera (Ashwagandha) with hydrocortisone in experimental animals (Albino rats),” J Med Plants Studies, 4, pp. 78–83. 20. Gupta, A. et al. (2014) “Lawsonia inermis-mediated synthesis of silver nanoparticles: activity against human pathogenic fungi and bacteria with special reference to formulation of an antimicrobial nanogel,” IET nanobiotechnology, 8(3), pp. 172–178. Available at: https://doi.org/10.1049/iet-nbt.2013.0015. 21. Gurunani, S.G. and Karadi, R.V. (2018) “Evaluation of traditionally claimed Salmalia malabarica (DC) Schot & Endlicher for anti-acne activity: An in-vitro and in-vivo approach,” Journal of Pharmacognosy and Phytochemistry, 7, pp. 2032–2037. 22. Hajazi, M.R., 1967. Bayaze Hajazi. Lahore: Bashir and Sons, p.56. 23. Imbert, I., Francoise, A. and Domloge, N. (2009) “Pisum Sativum Extract for Safe-and Self-tanning,” Cosmet Toiletries, 124. 24. Čižmárová, B. et al. (2023) “Flavonoids as promising natural compounds in the prevention and treatment of selected skin diseases,”International journal of molecular sciences, 24(7). Available at: https://doi.org/10.3390/ijms24076324 25. Iraji, F., Aghaei, A., Motamedi, R., Siahpoosh, A. and Karami, M.A., 2021. Comparison of topical herbal cream and 1% clindamycin gel for treatment of mild-to-moderate acne: A randomized clinical trial. Jundishapur Journal of Natural Pharmaceutical Products. Available at: [Accessed 22 Apr. 2025]. 26. Isfahlan, A.J. et al. (2010) “Anti-oxidant and anti-radical activities of the phenolic extracts of the hulls and shells of the Iranian almond (Prunus Amygdalus),” Turk J Biol, 34, pp. 165–173. 27. Kapoor, S. and Saraf, S. (2011) “Topical herbal therapies an alternative and complementary choice to combat acne,” Research journal of medicinal plant, 5(6), pp. 650–669. Available at: . 28. Kaur, P., Kaur, L. and Singh, A. (no date) Ethnobotanical and Pharmaceutical Properties of Medicinal Herb Cicer Arietinum-A. 29. Khan, A., 1920. Muheete Azam. Vol. 4. Lucknow: Munshi Nawal Kishore Press, p.138. 30. Khan, M.H., 1984. Datoorul Ilaj. Lucknow: Munshi Nawal Kishore Publishing House, p. 294. 31. Khān, H.A. (2004)Ḥāziq. Matia Mahal Delhi-110006: Hamraz publication. 32. Kim, M.-S. et al. (2013) “Olea europaea Linn (Oleaceae) fruit pulp extract exhibits potent antioxidant activity and attenuates neuroinflammatory responses in lipopolysaccharide-stimulated microglial cells,” Tropical Journal of Pharmaceutical Research, 12, pp. 357–362. 33. Kim, Y.-G., Lee, J.-H. and Lee, J. (2021) “Antibiofilm activities of fatty acids including myristoleic acid against Cutibacterium acnes via reduced cell hydrophobicity,” Phytomedicine: international journal of phytotherapy and phytopharmacology, 91(153710), p. 153710. Available at: https://doi.org/10.1016/j.phymed.2021.153710. 34. Kumar, P.P., Kumaravel, S. and Lalitha, C. (2010) “Screening of antioxidant activity, total phenolics and GC-MS study of Vitex negundo,” African Journal of Biochemistry Research, 4, pp. 191–195. 35. Kumar, R. et al. (2016) “Anti-inflammatory Effect of Picrorhiza kurroa in Experimental Models of Inflammation,” Planta medica, 82(16), pp. 1403–1409. Available at: https://doi.org/10.1055/s-0042-106304. 36. Lalla, J.K. et al. (2001) “Clinical trials of ayurvedic formulations in the treatment of acne vulgaris,” Journal of ethnopharmacology, 78(1), pp. 99–102. Available at: https://doi.org/10.1016/s0378- 8741(01)00323-3. 37. Lee, C.-J. et al. (2017) “Multiple Activities of Punica granatum Linne against Acne Vulgaris,” International journal of molecular sciences, 18(1), p. 141. Available at: https://doi.org/10.3390/ijms18010141. 38. Lee, C.-J. et al. (2020) “+)-Erythro-Δ8′-7S, 8R-dihydroxy-3, 3′, 5′-trimethoxy8-O-4′-neolignan, an Anti-Acne Component in Degreasing Myristica fragrans Houtt,” Molecules [Preprint]. 39. Lee, E.-J.; Bae, S.-Y.; NamKung, W.; Lee, Y.-H. Antibacterial and antiinflammatory effects of medicinal plants against acne-inducing bacteria. Journal of the Society (Kaur et al., n.d.)of Cosmetic Scientists of Korea 2010, 36, 57-63. 40. Letawe, C., Boone, M. and Piérard, G.E. (1998) “Digital image analysis of the effect of topically applied linoleic acid on acne microcomedones: DIGITAL ANALYSIS OF ACNE,” Clinical and experimental dermatology, 23(2), pp. 56–58. Available at: https://doi.org/10.1046/j.1365- 2230.1998.00315.x. 41. Lone, A.H. et al. (2012) “Effect of a Polyherbal Unani formulation in acne vulgaris: A preliminary study,” Journal of Ayurveda and integrative medicine, 3(4), pp. 180–183. Available at: . 42. Mastan, A., 2020. Effectiveness of treatment of Acne vulgaris (Busūr labaniyya): A comparative review between modern and Unani medicine. International Journal of Unani and Integrated Medicine, 4, pp. 1-4. Available at: [Accessed 22 April 2025]. 43. Muzafar, D., Bhat, M. and Malik, R. (2017) “Pharmacological Profile and Uses of Sumbul-ut-teeb (Nardostachys jatamansi),” in Unani System of Medicine. 44. Nam, C. et al. (2003) “Anti-acne effects of Oriental herb extracts: A novel screening method to select anti-acne agents,” Skin pharmacology and physiology, 16(2), pp. 84–90. Available at: https://doi.org/10.1159/000069030. 45. Narkhede, M.B., Wagh, A.E. and Rathi, A.M. (2012) “Anti-inflammatory activity of Vetiveria zizanioides (Linn.) root,” Journal of Pharmacy Research, 5, pp. 2016–2017. 46. Nigam, D., Singh, C. and Tiwari, U. (2014) “Evaluation of in vitro study of antioxidant and antibacterial activities of methanolic seed extract of Sesamum indicum,” Journal of Pharmacognosy and Phytochemistry, 3(4), pp. 1–05. 47. Orăşan, O. et al. (2017) “Antimicrobial activity and thiosulfinates profile of a formulation based on Allium cepa L. extract,” Open chemistry, 15(1), pp. 175–181. Available at: https://doi. org/10.1515/chem-2017-0021. 48. Pandya, D. and Pampaniya, P. (2013) “Effect of Shalmalyadilepa and Guduchyadivati in the management of Yauvanapidika (Acne),” Ayu, 34(2), p. 174. Available at: https://doi.org/10.4103/0974- 8520.119673. 49. Parveen, S. et al. (2009) “Clinical trial of Unani herbomineral cream to evaluate its topical effects on Acne vulgaris,” Indian journal of traditional knowledge, 8. 50. Parveen, S. et al. (2009) “Clinical trial of Unani herbomineral cream to evaluate its topical effects on Acne vulgaris,” Indian journal of traditional knowledge, 8. 51. Pasalar, M. et al. (2022) “Mechanistic support of traditional Persian medicine for the treatment of acne vulgaris: A scoping review,” Journal of cosmetic dermatology, 21(6), pp. 2338–2348. Available at: https://doi.org/10.1111/jocd.14464. 52. Prasad, S.B. and Bist, M., 2018. In vitro anti-acne activity of methanolic extract of dried fruit of Embelia ribes. International Journal of Pharmaceutical Quality Assurance, 9, pp.90–94. Available at: [Accessed 22 Apr. 2025]. 53. Rahat, I. and Sharma, S.K. (2021) “A Novel Antibacterial Topical Gel from Nigella sativa and Achyranthes aspera against Acne Causing Microorganisms,” Journal of pharmaceutical research international, pp. 57–63. Available at: https://doi.org/10.9734/jpri/2020/ v32i4131043. 54. Rajaiah Yogesh, H. et al. (2022) “Clinical study to assess efficacy and safety of Purifying Neem Face Wash in prevention and reduction of acne in healthy adults,” Journal of cosmetic dermatology, 21(7), pp. 2849–2858. Available at: https://doi.org/10.1111/jocd.14486. 55. Rasheed, A. et al. (2012) Formulation and evaluation of herbal antiacne moisturizer. Pakistan journal of pharmaceutical sciences. 56. Rasheed, A., Reddy, G.A.K., Lakshmi, S.M. and Kumar, C.A., 2011. Formulation and comparative evaluation of polyherbal anti-acne face wash gels. Pharmaceutical Biology, 49, pp.771–774. Available at: [Accessed 22 Apr. 2025]. 57. Rashid, N., Ahmed, H. and Shameem Dar, P. (2018) Alsi (Linum Usitatissimum(Linn):A potential multifaceted Unani drug. 58. Rhazi, Z., 1994. Al-Ḥāwi Fi’l Tibb. Vol. 23. Edited by Siddiqui, M.Y.H. Aligarh: Saba Publishers, pp. 36–37. 59. Saenprakob, P. (2020) “K Development of Facial Cleansing Anti-Acne Gel Formulation Using Terminalia chebula Extract,” Wichcha Journal Nakhon Si Thammarat Rajabhat University, 39, pp. 87–100. 60. Sathishkumar, P. et al. (2016) “Anti acne, anti dandruff and anti breast cancer efficacy of green synthesised silver nanoparticles using Coriandrum sativum leaf extract,” J Photochem Photobiol B, 163, pp. 69–76. 61. Seki, T. and Morohashi, M. (1993) “Effect of some alkaloids, flavonoids and triterpenoids, contents of Japanese-Chinese traditional herbal medicines, on the lipogenesis of sebaceous glands,” Skin pharmacology: the official journal of the Skin Pharmacology Society, 6(1), pp. 56–60. Available at: https://doi.org/10.1159/ 62. Shinkafi, S.A. and Anusa, H. (2013) “Antibacterial activity of citrus Limon on acne vulgaris (pimples),” IJSIT, 2, pp. 397–409. 63. Sīnā, I., 2010. Al-Qānūn fi’l Ṭibb (Urdu Translation by Ḥakīm Ghulām Ḥasnayn Kintūrī), Vol. IV. New Delhi: Idāra Kitāb al-Shifā, pp. 1420, 1432. 64. Syal, S., Pandit, V. and Ashwat, M.S. (2020) “Traditional Herbs to treat Acne Vulgaris,” Asian J.Pharm.Res, 10(3), pp. 195–201. 65. Tabasum, H. et al. (2014) “The effect of Unani antiacne formulation (Zimade Muhasa) on acne vulgaris: A single blind, randomized, controlled clinical trial,” J Pak Assoc Dermatol, 24, pp. 319–326. 66. Tabri, M., 1995. Moalijaat Buqratiyah. New Delhi: CCRUM, p. 252. 67. Tan, J. K., & Bhate, K. (2015). A global perspective on the epidemiology of acne. The British journal of dermatology, 172 Supple 1, 3–12. https://doi.org/10.1111/bjd.13462 68. Thappa, D.M. and Dogra, J. (1994) “Nodulocystic acne: Oral gugulipid versus tetracycline,” The journal of dermatology, 21(10), pp. 729– 731. Available at: . 69. Vohora, S.B., Naqvi, S.A. and Kumar, I. (1980) “Antipyretic, analgesic and antimicrobial studies on Sisymbrium irio,” Planta medica, 38(3), pp. 255–259. Available at: https://doi.org/10.1055/s-2008-1074870. 70. Wedler, J. et al. (2016) “In vitro modulation of inflammatory target gene expression by a polyphenol-enriched fraction of rose oil distillation waste water,” Fitoterapia, 114, pp. 56–62. Available at: https://doi.org/10.1016/j.fitote.2016.08.019. 71. Wei, M.-P. et al. (2021) “Saponin fraction from Sapindus mukorossi Gaertn as a novel cosmetic additive: Extraction, biological evaluation, analysis of anti-acne mechanism and toxicity prediction,” Journal of ethnopharmacology, 268(113552), p. 113552. Available at: https:// doi.org/10.1016/j.jep.2020.113552. 72. Wu, G.-X. et al. (2021) “Therapeutic efficacy of sesquiterpene farnesol in treatment of Cutibacterium acnes-induced dermal disorders,” Molecules (Basel, Switzerland), 26(18), p. 5723. Available at: https://doi.org/10.3390/molecules26185723. 73. Zhoh, C., Kwon, H. and Ahn, S. (2010) “Antioxidative and Antimicrobial Effects to Skin Flora of Extracts from Peel of Allium cepa L,” Asian Journal of Beauty and Cosmetology, 8, pp. 49–58. 74. Zu, Y. et al. (2010) “Activities of ten essential oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 cancer cells,” Molecules (Basel, Switzerland), 15(5), pp. 3200––3210. Available at: https://doi.org/10.3390/molecules15053200.
Title: A Scoping Review of Unani Medicinal Herbs Used to Treat Acne Vulgaris
Description:
Acne vulgaris (Buthūr Labaniyya) is among the most prevalent dermatological conditions worldwide, often leading to low self-esteem and negatively impacting the quality of life.
Conventional treatments have been widely used, but prolonged use has caused the emergence of resistance against acne-causing pathogens.
This paper explores the therapeutic potential of medicinal herbs mentioned in classical Unani literature approach to treating acne.
A comprehensive detailed search was conducted using classical Unani texts and modern scientific databases such as PubMed and Google Scholar to identify Unani medicinal herbs with anti-acne properties.
Various clinical studies have reported that the selected herbal drugs exhibit significant anti-acne effects, though further research is needed to determine the specific chemical constituents responsible for these properties.
Among the plant parts, roots were the most frequently mentioned for their therapeutic benefits.
1.
Abiya, S.
E.
et al.
(2018) “Antimicrobial activity of three medicinal plants against acne-inducing bacteria Propionibacterium acnes,” Brazilian Journal of Biological Sciences, 5(10), p.
e 315.
Available at: https://doi.
org/10.
21472/bjbs.
051008.
2.
Ahmad, F.
and Ahmad, H.
(2012) “Antibacterial Activity of Raphanus Sativus Linn,” Seed Extract.
GJMR, 12, pp.
25–33.
3.
Al-Hindawi, M.
K.
, Al-Deen, I.
H.
, Nabi, M.
H.
and Ismail, M.
A.
, 1989.
Anti-inflammatory activity of some Iraqi plants using intact rats.
Journal of Ethnopharmacology, 26, pp.
163–168.
4.
Anṭākī, D.
, 2010.
Tadhkira Ūlī al-Albāb.
New Delhi, India: Central Council for Research in Unani Medicine (CCRUM), Ministry of Health & Family Welfare, p.
87.
5.
Arzani, H.
M.
A.
, 2016.
Ṭibb-I Akbar.
Translated by Hussain, H.
M.
Deoband, India: Faisal Publications, pp.
697, 722.
6.
Baghdādī, I.
H.
, 2007.
Kitāb al-Mukhtārāt fiʼl Ṭibb.
Vol.
4.
New Delhi, India: Central Council for Research in Unani Medicine (CCRUM), Department of AYUSH, Ministry of Health & Family Welfare, pp.
188–189.
7.
Bashir, A.
et al.
(2011) “Comparative study of antimicrobial activities of Aloe vera extracts and antibiotics against isolates from skin infections,” African Journal of Biotechnology, 10, pp.
3835–3840.
8.
Batubara, I.
and Mitsunaga, T.
(2013) “Use of Indonesian medicinal plants products against acne,” Reviews in agricultural science, 1(0), pp.
11–30.
Available at: https://doi.
org/10.
7831/ras.
1.
11.
9.
Campisanoa, O.
L.
et al.
(2014) “Interkingdom transfer of the acne-causing agent, propionibacterium acnes, from human to grapevine,” Mol Biol Evol, 31, pp.
1059–1065.
10.
Chaudhary, S.
et al.
(2013) “The In vitro anti-acne activity of two unani drugs,” Ancient science of life, 33(1), p.
35.
Available at: https://doi.
org/10.
4103/0257-7941.
134594.
11.
Chen, C.
-H.
et al.
(2017) “Isoflavones and anti-inflammatory constituents from the fruits of Psoralea corylifolia,” Phytochemistry, 143, pp.
186–193.
Available at: .
12.
Dubey, D.
, Prashant, K.
and Jain, S.
(2009) “In-vitro antioxidant activity of the ethyl acetate extract of gum guggul (Commiphora mukul),” Proceedings of the Biological Forum-An Int J, pp.
32–35.
13.
Działo, M.
et al.
(2016) “The potential of plant phenolics in prevention and therapy of skin disorders,” International journal of molecular sciences, 17(2), p.
160.
Available at: https://doi.
org/10.
3390/ ijms17020160.
14.
Fajryana, A.
et al.
(2022) “Antibacterial activity of garlic extract (Allium sativum) using fermentation and non-fermentation towards Propionibacterium acne,” IOP conference series.
Earth and environmental science, 1083(1), p.
012070.
Available at: https://doi.
org/10.
1088/1755-1315/1083/1/012070.
15.
Fitzpatrick, T.
B.
et al.
(2001) “Colour Atlas and Synopsis of Clinical Dermatology, United States of America: Mc-Graw Hill Companies,” pp.
51–52.
16.
Ganaie, A.
A.
, Mishra, R.
P.
and Allaie, A.
H.
(2018) “Antioxidant activity of some extracts of Iris ensata,” Journal of Pharmacognosy and Phytochemistry, 7, pp.
230–235.
17.
Geelani, G.
, 1996.
Makhzane Hikmat.
Vol.
2.
Lahore: Basheer and Sons, pp.
689–691.
18.
Ghosh, V.
K.
et al.
(2011) “Different approaches of alternative medicines in acne vulgaris treatment,” Oriental pharmacy and experimental medicine, 11(1), pp.
1–9.
Available at: https://doi.
org/10.
1007/s13596-011-0006-6.
19.
Giri, K.
R.
(2016) “Comparative study of anti-inflammatory activity of Withania somnifera (Ashwagandha) with hydrocortisone in experimental animals (Albino rats),” J Med Plants Studies, 4, pp.
78–83.
20.
Gupta, A.
et al.
(2014) “Lawsonia inermis-mediated synthesis of silver nanoparticles: activity against human pathogenic fungi and bacteria with special reference to formulation of an antimicrobial nanogel,” IET nanobiotechnology, 8(3), pp.
172–178.
Available at: https://doi.
org/10.
1049/iet-nbt.
2013.
0015.
21.
Gurunani, S.
G.
and Karadi, R.
V.
(2018) “Evaluation of traditionally claimed Salmalia malabarica (DC) Schot & Endlicher for anti-acne activity: An in-vitro and in-vivo approach,” Journal of Pharmacognosy and Phytochemistry, 7, pp.
2032–2037.
22.
Hajazi, M.
R.
, 1967.
Bayaze Hajazi.
Lahore: Bashir and Sons, p.
56.
23.
Imbert, I.
, Francoise, A.
and Domloge, N.
(2009) “Pisum Sativum Extract for Safe-and Self-tanning,” Cosmet Toiletries, 124.
24.
Čižmárová, B.
et al.
(2023) “Flavonoids as promising natural compounds in the prevention and treatment of selected skin diseases,”International journal of molecular sciences, 24(7).
Available at: https://doi.
org/10.
3390/ijms24076324 25.
Iraji, F.
, Aghaei, A.
, Motamedi, R.
, Siahpoosh, A.
and Karami, M.
A.
, 2021.
Comparison of topical herbal cream and 1% clindamycin gel for treatment of mild-to-moderate acne: A randomized clinical trial.
Jundishapur Journal of Natural Pharmaceutical Products.
Available at: [Accessed 22 Apr.
2025].
26.
Isfahlan, A.
J.
et al.
(2010) “Anti-oxidant and anti-radical activities of the phenolic extracts of the hulls and shells of the Iranian almond (Prunus Amygdalus),” Turk J Biol, 34, pp.
165–173.
27.
Kapoor, S.
and Saraf, S.
(2011) “Topical herbal therapies an alternative and complementary choice to combat acne,” Research journal of medicinal plant, 5(6), pp.
650–669.
Available at: .
28.
Kaur, P.
, Kaur, L.
and Singh, A.
(no date) Ethnobotanical and Pharmaceutical Properties of Medicinal Herb Cicer Arietinum-A.
29.
Khan, A.
, 1920.
Muheete Azam.
Vol.
4.
Lucknow: Munshi Nawal Kishore Press, p.
138.
30.
Khan, M.
H.
, 1984.
Datoorul Ilaj.
Lucknow: Munshi Nawal Kishore Publishing House, p.
294.
31.
Khān, H.
A.
(2004)Ḥāziq.
Matia Mahal Delhi-110006: Hamraz publication.
32.
Kim, M.
-S.
et al.
(2013) “Olea europaea Linn (Oleaceae) fruit pulp extract exhibits potent antioxidant activity and attenuates neuroinflammatory responses in lipopolysaccharide-stimulated microglial cells,” Tropical Journal of Pharmaceutical Research, 12, pp.
357–362.
33.
Kim, Y.
-G.
, Lee, J.
-H.
and Lee, J.
(2021) “Antibiofilm activities of fatty acids including myristoleic acid against Cutibacterium acnes via reduced cell hydrophobicity,” Phytomedicine: international journal of phytotherapy and phytopharmacology, 91(153710), p.
153710.
Available at: https://doi.
org/10.
1016/j.
phymed.
2021.
153710.
34.
Kumar, P.
P.
, Kumaravel, S.
and Lalitha, C.
(2010) “Screening of antioxidant activity, total phenolics and GC-MS study of Vitex negundo,” African Journal of Biochemistry Research, 4, pp.
191–195.
35.
Kumar, R.
et al.
(2016) “Anti-inflammatory Effect of Picrorhiza kurroa in Experimental Models of Inflammation,” Planta medica, 82(16), pp.
1403–1409.
Available at: https://doi.
org/10.
1055/s-0042-106304.
36.
Lalla, J.
K.
et al.
(2001) “Clinical trials of ayurvedic formulations in the treatment of acne vulgaris,” Journal of ethnopharmacology, 78(1), pp.
99–102.
Available at: https://doi.
org/10.
1016/s0378- 8741(01)00323-3.
37.
Lee, C.
-J.
et al.
(2017) “Multiple Activities of Punica granatum Linne against Acne Vulgaris,” International journal of molecular sciences, 18(1), p.
141.
Available at: https://doi.
org/10.
3390/ijms18010141.
38.
Lee, C.
-J.
et al.
(2020) “+)-Erythro-Δ8′-7S, 8R-dihydroxy-3, 3′, 5′-trimethoxy8-O-4′-neolignan, an Anti-Acne Component in Degreasing Myristica fragrans Houtt,” Molecules [Preprint].
39.
Lee, E.
-J.
; Bae, S.
-Y.
; NamKung, W.
; Lee, Y.
-H.
Antibacterial and antiinflammatory effects of medicinal plants against acne-inducing bacteria.
Journal of the Society (Kaur et al.
, n.
d.
)of Cosmetic Scientists of Korea 2010, 36, 57-63.
40.
Letawe, C.
, Boone, M.
and Piérard, G.
E.
(1998) “Digital image analysis of the effect of topically applied linoleic acid on acne microcomedones: DIGITAL ANALYSIS OF ACNE,” Clinical and experimental dermatology, 23(2), pp.
56–58.
Available at: https://doi.
org/10.
1046/j.
1365- 2230.
1998.
00315.
x.
41.
Lone, A.
H.
et al.
(2012) “Effect of a Polyherbal Unani formulation in acne vulgaris: A preliminary study,” Journal of Ayurveda and integrative medicine, 3(4), pp.
180–183.
Available at: .
42.
Mastan, A.
, 2020.
Effectiveness of treatment of Acne vulgaris (Busūr labaniyya): A comparative review between modern and Unani medicine.
International Journal of Unani and Integrated Medicine, 4, pp.
1-4.
Available at: [Accessed 22 April 2025].
43.
Muzafar, D.
, Bhat, M.
and Malik, R.
(2017) “Pharmacological Profile and Uses of Sumbul-ut-teeb (Nardostachys jatamansi),” in Unani System of Medicine.
44.
Nam, C.
et al.
(2003) “Anti-acne effects of Oriental herb extracts: A novel screening method to select anti-acne agents,” Skin pharmacology and physiology, 16(2), pp.
84–90.
Available at: https://doi.
org/10.
1159/000069030.
45.
Narkhede, M.
B.
, Wagh, A.
E.
and Rathi, A.
M.
(2012) “Anti-inflammatory activity of Vetiveria zizanioides (Linn.
) root,” Journal of Pharmacy Research, 5, pp.
2016–2017.
46.
Nigam, D.
, Singh, C.
and Tiwari, U.
(2014) “Evaluation of in vitro study of antioxidant and antibacterial activities of methanolic seed extract of Sesamum indicum,” Journal of Pharmacognosy and Phytochemistry, 3(4), pp.
1–05.
47.
Orăşan, O.
et al.
(2017) “Antimicrobial activity and thiosulfinates profile of a formulation based on Allium cepa L.
extract,” Open chemistry, 15(1), pp.
175–181.
Available at: https://doi.
org/10.
1515/chem-2017-0021.
48.
Pandya, D.
and Pampaniya, P.
(2013) “Effect of Shalmalyadilepa and Guduchyadivati in the management of Yauvanapidika (Acne),” Ayu, 34(2), p.
174.
Available at: https://doi.
org/10.
4103/0974- 8520.
119673.
49.
Parveen, S.
et al.
(2009) “Clinical trial of Unani herbomineral cream to evaluate its topical effects on Acne vulgaris,” Indian journal of traditional knowledge, 8.
50.
Parveen, S.
et al.
(2009) “Clinical trial of Unani herbomineral cream to evaluate its topical effects on Acne vulgaris,” Indian journal of traditional knowledge, 8.
51.
Pasalar, M.
et al.
(2022) “Mechanistic support of traditional Persian medicine for the treatment of acne vulgaris: A scoping review,” Journal of cosmetic dermatology, 21(6), pp.
2338–2348.
Available at: https://doi.
org/10.
1111/jocd.
14464.
52.
Prasad, S.
B.
and Bist, M.
, 2018.
In vitro anti-acne activity of methanolic extract of dried fruit of Embelia ribes.
International Journal of Pharmaceutical Quality Assurance, 9, pp.
90–94.
Available at: [Accessed 22 Apr.
2025].
53.
Rahat, I.
and Sharma, S.
K.
(2021) “A Novel Antibacterial Topical Gel from Nigella sativa and Achyranthes aspera against Acne Causing Microorganisms,” Journal of pharmaceutical research international, pp.
57–63.
Available at: https://doi.
org/10.
9734/jpri/2020/ v32i4131043.
54.
Rajaiah Yogesh, H.
et al.
(2022) “Clinical study to assess efficacy and safety of Purifying Neem Face Wash in prevention and reduction of acne in healthy adults,” Journal of cosmetic dermatology, 21(7), pp.
2849–2858.
Available at: https://doi.
org/10.
1111/jocd.
14486.
55.
Rasheed, A.
et al.
(2012) Formulation and evaluation of herbal antiacne moisturizer.
Pakistan journal of pharmaceutical sciences.
56.
Rasheed, A.
, Reddy, G.
A.
K.
, Lakshmi, S.
M.
and Kumar, C.
A.
, 2011.
Formulation and comparative evaluation of polyherbal anti-acne face wash gels.
Pharmaceutical Biology, 49, pp.
771–774.
Available at: [Accessed 22 Apr.
2025].
57.
Rashid, N.
, Ahmed, H.
and Shameem Dar, P.
(2018) Alsi (Linum Usitatissimum(Linn):A potential multifaceted Unani drug.
58.
Rhazi, Z.
, 1994.
Al-Ḥāwi Fi’l Tibb.
Vol.
23.
Edited by Siddiqui, M.
Y.
H.
Aligarh: Saba Publishers, pp.
36–37.
59.
Saenprakob, P.
(2020) “K Development of Facial Cleansing Anti-Acne Gel Formulation Using Terminalia chebula Extract,” Wichcha Journal Nakhon Si Thammarat Rajabhat University, 39, pp.
87–100.
60.
Sathishkumar, P.
et al.
(2016) “Anti acne, anti dandruff and anti breast cancer efficacy of green synthesised silver nanoparticles using Coriandrum sativum leaf extract,” J Photochem Photobiol B, 163, pp.
69–76.
61.
Seki, T.
and Morohashi, M.
(1993) “Effect of some alkaloids, flavonoids and triterpenoids, contents of Japanese-Chinese traditional herbal medicines, on the lipogenesis of sebaceous glands,” Skin pharmacology: the official journal of the Skin Pharmacology Society, 6(1), pp.
56–60.
Available at: https://doi.
org/10.
1159/ 62.
Shinkafi, S.
A.
and Anusa, H.
(2013) “Antibacterial activity of citrus Limon on acne vulgaris (pimples),” IJSIT, 2, pp.
397–409.
63.
Sīnā, I.
, 2010.
Al-Qānūn fi’l Ṭibb (Urdu Translation by Ḥakīm Ghulām Ḥasnayn Kintūrī), Vol.
IV.
New Delhi: Idāra Kitāb al-Shifā, pp.
1420, 1432.
64.
Syal, S.
, Pandit, V.
and Ashwat, M.
S.
(2020) “Traditional Herbs to treat Acne Vulgaris,” Asian J.
Pharm.
Res, 10(3), pp.
195–201.
65.
Tabasum, H.
et al.
(2014) “The effect of Unani antiacne formulation (Zimade Muhasa) on acne vulgaris: A single blind, randomized, controlled clinical trial,” J Pak Assoc Dermatol, 24, pp.
319–326.
66.
Tabri, M.
, 1995.
Moalijaat Buqratiyah.
New Delhi: CCRUM, p.
252.
67.
Tan, J.
K.
, & Bhate, K.
(2015).
A global perspective on the epidemiology of acne.
The British journal of dermatology, 172 Supple 1, 3–12.
https://doi.
org/10.
1111/bjd.
13462 68.
Thappa, D.
M.
and Dogra, J.
(1994) “Nodulocystic acne: Oral gugulipid versus tetracycline,” The journal of dermatology, 21(10), pp.
729– 731.
Available at: .
69.
Vohora, S.
B.
, Naqvi, S.
A.
and Kumar, I.
(1980) “Antipyretic, analgesic and antimicrobial studies on Sisymbrium irio,” Planta medica, 38(3), pp.
255–259.
Available at: https://doi.
org/10.
1055/s-2008-1074870.
70.
Wedler, J.
et al.
(2016) “In vitro modulation of inflammatory target gene expression by a polyphenol-enriched fraction of rose oil distillation waste water,” Fitoterapia, 114, pp.
56–62.
Available at: https://doi.
org/10.
1016/j.
fitote.
2016.
08.
019.
71.
Wei, M.
-P.
et al.
(2021) “Saponin fraction from Sapindus mukorossi Gaertn as a novel cosmetic additive: Extraction, biological evaluation, analysis of anti-acne mechanism and toxicity prediction,” Journal of ethnopharmacology, 268(113552), p.
113552.
Available at: https:// doi.
org/10.
1016/j.
jep.
2020.
113552.
72.
Wu, G.
-X.
et al.
(2021) “Therapeutic efficacy of sesquiterpene farnesol in treatment of Cutibacterium acnes-induced dermal disorders,” Molecules (Basel, Switzerland), 26(18), p.
5723.
Available at: https://doi.
org/10.
3390/molecules26185723.
73.
Zhoh, C.
, Kwon, H.
and Ahn, S.
(2010) “Antioxidative and Antimicrobial Effects to Skin Flora of Extracts from Peel of Allium cepa L,” Asian Journal of Beauty and Cosmetology, 8, pp.
49–58.
74.
Zu, Y.
et al.
(2010) “Activities of ten essential oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 cancer cells,” Molecules (Basel, Switzerland), 15(5), pp.
3200––3210.
Available at: https://doi.
org/10.
3390/molecules15053200.

Related Results

Kadar serum 25-hidroksi vitamin D berkorelasi negatif dengan interleukin-17 pada acne vulgaris derajat berat
Kadar serum 25-hidroksi vitamin D berkorelasi negatif dengan interleukin-17 pada acne vulgaris derajat berat
Background: Acne vulgaris is a common skin disease in Indonesia. Inflammation is a key factor in its development. 25-hydroxy vitamin D or 25(OH)D is considered to have antioxidant ...
Psychological impact of acne and post inflammatory hyperpigmentation among Sudanese women
Psychological impact of acne and post inflammatory hyperpigmentation among Sudanese women
Abstract Background: Acne vulgaris is a chronic inflammatory disorder of the skin which often causes a negative impact on a woman's psychological state and quality of life....
Psychological Impact of Acne and Post Inflammatory Hyperpigmentation Among Sudanese Women
Psychological Impact of Acne and Post Inflammatory Hyperpigmentation Among Sudanese Women
<i>Introduction: </i>Acne vulgaris is a chronic inflammatory disorder of the skin which often causes a negative impact on a woman's psychologic...
An Overview About Acne Vulgaris
An Overview About Acne Vulgaris
Background: Acne vulgaris (acne) is a long-term inflammatory skin disease. Typical features of acne that  often appears in adolescents on the forehead include visible, clinically r...
Unveiling the Role of High Glycemic Diets on Acne Formation
Unveiling the Role of High Glycemic Diets on Acne Formation
Background: Acne vulgaris is a prevalent dermatological condition that affects a significant proportion of the global population, particularly adolescents and young adults. Emergin...
Association of Dairy Foods in Acne Vulgaris
Association of Dairy Foods in Acne Vulgaris
Background: Acne vulgaris is one of the most commonly found skin problems affecting teenagers and adolescents. Dietary foods particularly dairy products consist of milk or any of i...
Hubungan Stress Dan Kebersihan Wajah Terhadap Kejadian Akne Vulgaris Pada Mahasiswa Kedokteran Universitas Malahayati
Hubungan Stress Dan Kebersihan Wajah Terhadap Kejadian Akne Vulgaris Pada Mahasiswa Kedokteran Universitas Malahayati
ABSTRACT: RELATIONSHIP OF STRESS AND FACE CLEANLINESS TO THE EVENT OF VULGARIS IN MEDICAL STUDENTS OF UNIVERSITAS MALAHAYATI Background: Acne vulgaris is a disorder of the sebaceou...
Correlation between Stress Scale and Severity of Acne Vulgaris
Correlation between Stress Scale and Severity of Acne Vulgaris
Background: Acne vulgaris (AV) is a chronic inflammatory disease of pilosebaceous follicles with polymorphic lesions, consist of blackheads, papules, pustules and nodules with vary...

Back to Top