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Anti-oxidant and Antiproliferative Activities of Mongolian Medicinal Plant Extracts and Structure Isolation of Gnetin-H Compound
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Background:
Reactive oxygen species are involved in the etiology and progress of many
kinds of diseases such as cancer, cardiovascular diseases, inflammatory and neurodegenerative disorders.
Epidemiological studies reported that fruits, vegetables, and wines containing a high percentage
of phenolics and flavonoids showed a positive impact in treating inflammatory diseases, reducing
cancer risk, and increasing life expectancy.
Objective:
Some Mongolian medicinal plants were studied for their antioxidant activity and anticancer
effects.
Methods:
Selected Mongolian medicinal plant extracts were examined for their antioxidant activity
by the DPPH-radical scavenging assay, the content of phenolics and flavonoids by Folin-Ciocalteu
and the Dowd method, respectively, and anti-cancer activities in human hepatoma cell line HepG2
cells by MTT assay.
Results:
Methanol extract from Hippophae rhamnoides L. leaf and ethanol extract from Artemisia
macrocephala Jacq. ex Bess. showed the highest efficiency to scavenge free radicals. Ethanol extracts
from Hippophae rhamnoides L. grain and Paeonio anomala L. leaf showed the highest total phenolics
content, whereas Hippophae rhamnoides L. fruit methanol extract and ethanol extract from Caragana
leucophloea pojark. mentioned the highest flavonoids content. The Artemisia macrocephala
Jacq. ex Bess seed wallet and Paeonia anomala L. seed wallet showed the most potent antiproliferative
effects against human liver cancer HepG2 cell line. Gnetin-H compound was isolated from the
Paeonio anomala L. seed wallet extract, and its molecular structure was determined by 1H and 13C
NMR spectrum and IR spectroscopy methods.
Conclusion:
The screening study on anti-oxidative effects of 21 extracts from 15 Mongolian medicinal
plants showed anti-oxidative activities and was rich in phenolics and flavonoids. Among these,
methanol extract of the Hippophae rhamnoides L. leaf showed a better anti-oxidative effect than the
ethanol extract. Artemisia macrocephala Jacq. ex Bess and Paeonia anomala L. seed wallet mentioned
the best anti-cancer effects. Gnetin-H, methyl gallate, ethylgallate were the major components
in the extract from the Paeonio anomala L. seed wallet. Finally, the molecular structure of gnetin-H
was determined by NMR and IR spectroscopy. Further investigation, especially in vivo antioxidant
activity, is needed to justify the use of a natural source of antioxidants to prevent the progression of
diseases such as cancer.
Bentham Science Publishers Ltd.
Title: Anti-oxidant and Antiproliferative Activities of Mongolian Medicinal Plant Extracts and Structure Isolation of Gnetin-H Compound
Description:
Background:
Reactive oxygen species are involved in the etiology and progress of many
kinds of diseases such as cancer, cardiovascular diseases, inflammatory and neurodegenerative disorders.
Epidemiological studies reported that fruits, vegetables, and wines containing a high percentage
of phenolics and flavonoids showed a positive impact in treating inflammatory diseases, reducing
cancer risk, and increasing life expectancy.
Objective:
Some Mongolian medicinal plants were studied for their antioxidant activity and anticancer
effects.
Methods:
Selected Mongolian medicinal plant extracts were examined for their antioxidant activity
by the DPPH-radical scavenging assay, the content of phenolics and flavonoids by Folin-Ciocalteu
and the Dowd method, respectively, and anti-cancer activities in human hepatoma cell line HepG2
cells by MTT assay.
Results:
Methanol extract from Hippophae rhamnoides L.
leaf and ethanol extract from Artemisia
macrocephala Jacq.
ex Bess.
showed the highest efficiency to scavenge free radicals.
Ethanol extracts
from Hippophae rhamnoides L.
grain and Paeonio anomala L.
leaf showed the highest total phenolics
content, whereas Hippophae rhamnoides L.
fruit methanol extract and ethanol extract from Caragana
leucophloea pojark.
mentioned the highest flavonoids content.
The Artemisia macrocephala
Jacq.
ex Bess seed wallet and Paeonia anomala L.
seed wallet showed the most potent antiproliferative
effects against human liver cancer HepG2 cell line.
Gnetin-H compound was isolated from the
Paeonio anomala L.
seed wallet extract, and its molecular structure was determined by 1H and 13C
NMR spectrum and IR spectroscopy methods.
Conclusion:
The screening study on anti-oxidative effects of 21 extracts from 15 Mongolian medicinal
plants showed anti-oxidative activities and was rich in phenolics and flavonoids.
Among these,
methanol extract of the Hippophae rhamnoides L.
leaf showed a better anti-oxidative effect than the
ethanol extract.
Artemisia macrocephala Jacq.
ex Bess and Paeonia anomala L.
seed wallet mentioned
the best anti-cancer effects.
Gnetin-H, methyl gallate, ethylgallate were the major components
in the extract from the Paeonio anomala L.
seed wallet.
Finally, the molecular structure of gnetin-H
was determined by NMR and IR spectroscopy.
Further investigation, especially in vivo antioxidant
activity, is needed to justify the use of a natural source of antioxidants to prevent the progression of
diseases such as cancer.
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