Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Gassman Oxindole Synthesis
View through CrossRef
Abstract
This reaction is a multistep process (but a one‐pot reaction) for preparing oxindole with an electron‐withdrawing group involving sequential treatment of aniline with
tert
‐butyl hypochlorite, ethyl (methylthio)acetate, triethylamine, and hydrochloric acid and final treatment with zinc or Raney nickel for the desulfurization and is referred to as the Gassman oxindole synthesis. Further oxidation of the resulting oxindole by
N
chlorosuccinamide/HgO or by direct air oxidation has been reported to produce relevant isatin. This reaction has been found to tolerate a variety of functional groups, which differ in electron character; besides this,
N
alkylanilines are also found suitable for this reaction. This reaction is useful in the synthesis of oxindoles and isatins.
Title: Gassman Oxindole Synthesis
Description:
Abstract
This reaction is a multistep process (but a one‐pot reaction) for preparing oxindole with an electron‐withdrawing group involving sequential treatment of aniline with
tert
‐butyl hypochlorite, ethyl (methylthio)acetate, triethylamine, and hydrochloric acid and final treatment with zinc or Raney nickel for the desulfurization and is referred to as the Gassman oxindole synthesis.
Further oxidation of the resulting oxindole by
N
chlorosuccinamide/HgO or by direct air oxidation has been reported to produce relevant isatin.
This reaction has been found to tolerate a variety of functional groups, which differ in electron character; besides this,
N
alkylanilines are also found suitable for this reaction.
This reaction is useful in the synthesis of oxindoles and isatins.
Related Results
Synthesis, characterization and antimicrobial activity of some new N-substituted-oxindole derivatives
Synthesis, characterization and antimicrobial activity of some new N-substituted-oxindole derivatives
The aim of this research is the synthesis of new heterocyclic derivatives containing 4-oxo-thiazolidines, tetrazol or oxoazetidin ring from oxindole. To obtain these derivatives, o...
DNA Fragmentation, Cell Cycle Arrest, and Docking Study of Novel Bis Spiro-cyclic 2-oxindole of Pyrimido[4,5-b]quinoline-4,6-dione Derivatives Against Breast Carcinoma
DNA Fragmentation, Cell Cycle Arrest, and Docking Study of Novel Bis Spiro-cyclic 2-oxindole of Pyrimido[4,5-b]quinoline-4,6-dione Derivatives Against Breast Carcinoma
Background:
Recently, it is reported that heterocycles containing pyrimidoquinoline
moiety show a broad spectrum of medicinal and pharmacological properties including anticancer,
...
Synthesis of Spiro-oxindoles (Spiroindolones) via Oxidative Ring Contraction
Approach
Synthesis of Spiro-oxindoles (Spiroindolones) via Oxidative Ring Contraction
Approach
Abstract:
Ring contraction reaction is among the several vital strategies in organic synthesis that
can provide very diversified and useful molecular architecture. Among these stra...
1,2,3‐Triazole derivatives of 3‐ferrocenylidene‐2‐oxindole: Synthesis, characterization, electrochemical and antimicrobial evaluation
1,2,3‐Triazole derivatives of 3‐ferrocenylidene‐2‐oxindole: Synthesis, characterization, electrochemical and antimicrobial evaluation
A series of bioactive, triazole‐linked benzyl, aryl, sugar and aliphatic conjugates of 3‐ferrocenylidene‐oxindole have been synthesized. A facile 1,3‐dipolar‐Huisgen coupling react...
Electrochemical Detection of Chloride Ions by Copper (II) Complex with Mixed Ligand of Oxindole Derivative and Dithiocarbamates Moiety
Electrochemical Detection of Chloride Ions by Copper (II) Complex with Mixed Ligand of Oxindole Derivative and Dithiocarbamates Moiety
The present work describes the synthesis of a new copper (II) complex with bidentate ligands based on oxindole (indolin-2-one) derivatives, namely: 1H,1′H,1″H-[2,3′:2′,3″-terbenzo[...
Melville et Dante. Vittorio Gassman : Ulisse e la balena bianca
Melville et Dante. Vittorio Gassman : Ulisse e la balena bianca
Après un très bref rappel de l’expérience américaine de Vittorio Gassman en tant qu’acteur de cinéma, cet article centre son propos sur l’acteur et auteur de théâtre, et plus parti...
Flavin‐Dependent Monooxygenases NotI and NotI′ Mediate Spiro‐Oxindole Formation in Biosynthesis of the Notoamides
Flavin‐Dependent Monooxygenases NotI and NotI′ Mediate Spiro‐Oxindole Formation in Biosynthesis of the Notoamides
Abstract
The fungal indole alkaloids are a unique class of complex molecules that have a characteristic bicyclo[2.2.2]diazaoctane ring and fr...
Flavin-Dependent Monooxygenases NotI and NotI′ Mediate Spiro-Oxindole Formation in Biosynthesis of the Notoamides
Flavin-Dependent Monooxygenases NotI and NotI′ Mediate Spiro-Oxindole Formation in Biosynthesis of the Notoamides
The fungal indole alkaloids are a unique class of
complex molecules that have a characteristic bicyclo[2.2.2]diazaoctane ring and frequently contain a spiro-oxindole moiety. While...