Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes
View through CrossRef
Topoisomerases, common targets for anti-tumor therapeutics, are crucial enzymes for DNA replication, transcription, and many other aspects of DNA metabolism. The potential anti-cancer effect of thiosemicarbazones (TSC) and metal-TSC complexes has been demonstrated by targeting several biological processes, including DNA metabolism. Human topoisomerases were discovered among the molecular targets for TSCs, and metal-chelated TSCs specifically displayed significant inhibition. The processes by which metal-TSCs or TSCs inhibit topoisomerases are still being studied. In this brief review, we summarize the TSCs and metal-TSCs that inhibit various types of human topoisomerases.
Title: Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes
Description:
Topoisomerases, common targets for anti-tumor therapeutics, are crucial enzymes for DNA replication, transcription, and many other aspects of DNA metabolism.
The potential anti-cancer effect of thiosemicarbazones (TSC) and metal-TSC complexes has been demonstrated by targeting several biological processes, including DNA metabolism.
Human topoisomerases were discovered among the molecular targets for TSCs, and metal-chelated TSCs specifically displayed significant inhibition.
The processes by which metal-TSCs or TSCs inhibit topoisomerases are still being studied.
In this brief review, we summarize the TSCs and metal-TSCs that inhibit various types of human topoisomerases.
Related Results
Kinetic Study of DNA Topoisomerases by Supercoiling-Dependent
Fluorescence Quenching
Kinetic Study of DNA Topoisomerases by Supercoiling-Dependent
Fluorescence Quenching
Abstract
DNA topoisomerases are essential enzymes for all living organisms and important targets for anticancer drugs and antibiotics. Although DNA topoisomerases...
Topoisomerase Assays
Topoisomerase Assays
AbstractTopoisomerases are enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of DNA top...
Ruthenium(II) complexes of hybrid 8‐hydroxyquinoline–thiosemicarbazone ligands: synthesis, characterization and catalytic applications
Ruthenium(II) complexes of hybrid 8‐hydroxyquinoline–thiosemicarbazone ligands: synthesis, characterization and catalytic applications
A series of new hexa‐coordinated ruthenium(II) hydroxyquinoline–thiosemicarbazone complexes of the type [Ru(CO)(EPh3)(B)(L)] (E = P or As; B = PPh3, AsPh3 or Py; L = hydroxyquinoli...
Ionic complexes of biodegradable polyelectrolytes
Ionic complexes of biodegradable polyelectrolytes
Biopolymers are polymers produced by living organisms. A more broad classification would embrace also those polymers synthesized from renewable sources which are able to display bi...
DESIGN, SCREENING AND EXPLORING NOVEL METAL-THIOSEMICARBAZONE COMPLEXES TARGETING HT-29 CELL LINE USING QSPR-BASED IN SILICO MODELING
DESIGN, SCREENING AND EXPLORING NOVEL METAL-THIOSEMICARBAZONE COMPLEXES TARGETING HT-29 CELL LINE USING QSPR-BASED IN SILICO MODELING
In silico models were used to calculate the stability constants (logb11) of metal ions and thiosemicarbazone in complex solutions. The 0-3D molecular descriptors, physicochemical, ...
Synthesis, Characterization and Biological Evaluation of Metal Complexes (Zinc, Iron, Copper, Antimony, and Tin) of Sulphanilamide Derivatives
Synthesis, Characterization and Biological Evaluation of Metal Complexes (Zinc, Iron, Copper, Antimony, and Tin) of Sulphanilamide Derivatives
Due to the emerging problem of antibiotic resistance. Its high time that new medicinal products need to be investigated to tackle this problem. Synthesis and characterizat...
Synthesis, Physicochemical Studies and Powder X‐Ray Diffraction Analyses for New Niclosamide Metal Complexes with Significant Bioactive Behavior
Synthesis, Physicochemical Studies and Powder X‐Ray Diffraction Analyses for New Niclosamide Metal Complexes with Significant Bioactive Behavior
Abstract
This work underlines some important features for the research on metal complexes of Niclosamide as antioxidants and antimicrobial ev...
Mechanism of action of a new organometallic compound inhibitor of topoisomerase I in adenocarcinomas
Mechanism of action of a new organometallic compound inhibitor of topoisomerase I in adenocarcinomas
Mécanisme d'action d'un nouveau composé organométallique inhibiteur des topoisomérases I d’adénocarcinomes
Les topoisomérases sont les cibles d'inhibiteurs en chimi...