Synthesis, Characterization and Biological Evaluation of Metal Complexes (Zinc, Iron, Copper, Antimony, and Tin) of Sulphanilamide Derivatives

Due to the emerging problem of antibiotic resistance. Its high time that new medicinal products need to be investigated to tackle this problem. Synthesis and characterization of metal-based Sulfa drugs have gained a lot of attention in past few decades, because of their enhanced therapeutic applications. Current study includes the synthesis and characterization of a sulphanilamide ligand and its metal complexes by reacting Sulphanilamide and P-toluene sulphonyl chloride and then reacting them with ten different metals like zinc, copper, iron, tin and antimony to make their metal complexes and to prepare new metallodrugs with improved biological activities. Biological activity of the compounds were determined by screening ligand and metal complexes for antibacterial, antifungal and antioxidant potential. All complexes were successfully made and are found to have significant antibacterial, antifungal and antioxidant activity. In Infrared Spectroscopes the absence of primary stretch from the ligand in metal complexes confirms the attachment of metal. The appearance of new IR band which were absent in ligand spectra are assigned as metal bonds with NH and support the formation of metal complexes. In the 1 H NMR and 13 C NMR spectra of all complexes, the change in the appearance of peaks and formation of proton signals for the groups attached to metals confirmed the formation of complexes. In the spectra of 13 C NMR of all complexes the peaks representing specific carbon confirm the formation of complexes. The groups attached with added metal complexes also showed their peaks which are in agreement with the proposed structures. The results of biological assays showed improved antibacterial, antifungal and antioxidant activity in all metal complexes than the ligand.