Extraction, Isolation Characterization and Antiasthamatic Activity of The Leaves of Abelmoschus Esculenutus (okra)

Aims: The aim of study was to evaluate the scientific basis for the traditional use of Amebelmoschus esculentus leaves. Materials and Methods: In the present study, petroleum ether extract of Abelmoschus esculentus leaves was evaluated for preliminary phytochemical screening and antiasthmatic activity using histamine induced bronchospasm and histamine induced constriction on isolated goat tracheal chain at different dose levels. Student's t-Test and Dunett's test were used for statistical analysis. Results: The result of present investigation showed that the petroleum ether extract of Abelmoschus esculentus significantly (P<0.001) decreased the bronchospasm induced by histamine and It also decreased the histamine induce constriction on isolated goat trachea in dose-dependent manner. Phytochemical studies revealed the presence of flavonoids, and phenolic compounds in the extract. Conclusions: The present study concludes that the antiasthmatic activity of ethanolic extract of A.esculentus leaves may be due to the presence of flavonoids, Alkaloids glycosides, tannins, protein. Antiasthmatic action of the A. esculentus could be due to its antihistaminic, anticholinergic and mast-cell-stabilizing property.