Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Synthesis, structural elucidation, DFT, and antimicrobial evaluation of novel Cu(II)-hydrazone Schiff base complexes
View through CrossRef
Herein, we report the synthesis, characterization, antimicrobial evaluation, and density functional theory (DFT) analysis of two hydrazone Schiff bases (L1 and L2) and their homoleptic and heteroleptic copper(II) complexes (Cu(L1)2, Cu(L2)2, and CuL1L2). The compounds were successfully characterized via Fourier transform infrared (FTIR), ultraviolet-visible (UV-Vis), and nuclear magnetic resonance (NMR) spectroscopies, as well as melting point determination, conductivity and magnetic susceptibility measurements, mass spectrometry, thermogravimetry, and X-ray crystallography. Antimicrobial activity was evaluated against some bacteria and fungi using the agar diffusion method. DFT analysis was performed with a hybrid functional, B3LYP, and Def2TZVP basis set. NMR and FTIR spectra confirmed ligand formation and coordination of the metal through imine and carbonyl groups. A single crystal was obtained only for L1 after several attempts. Conductivity data, UV-visible spectra, and magnetic moment values of the complexes were all in favor of the square planar geometry. All the synthesized compounds displayed satisfactory antimicrobial potency, with L2 and CuL1L2 showing superior activity against Pseudomonas flurescens and Candida albican, compared to the standard drug (Chloramphenicol). The DFT results not only corroborated the experimental findings but also provided valuable insights into the mechanism of action of the synthesized compounds.
KEY WORDS: Antimicrobial resistance, DFT, Homoleptic and heteroleptic copper(II) complexes, Hydrazone Schiff base, p-toluic acid hydrazide
Bull. Chem. Soc. Ethiop. 2026, 40(10), 2097-2114.
DOI: https://dx.doi.org/10.4314/bcse.v40i10.4
African Journals Online (AJOL)
Title: Synthesis, structural elucidation, DFT, and antimicrobial evaluation of novel Cu(II)-hydrazone Schiff base complexes
Description:
Herein, we report the synthesis, characterization, antimicrobial evaluation, and density functional theory (DFT) analysis of two hydrazone Schiff bases (L1 and L2) and their homoleptic and heteroleptic copper(II) complexes (Cu(L1)2, Cu(L2)2, and CuL1L2).
The compounds were successfully characterized via Fourier transform infrared (FTIR), ultraviolet-visible (UV-Vis), and nuclear magnetic resonance (NMR) spectroscopies, as well as melting point determination, conductivity and magnetic susceptibility measurements, mass spectrometry, thermogravimetry, and X-ray crystallography.
Antimicrobial activity was evaluated against some bacteria and fungi using the agar diffusion method.
DFT analysis was performed with a hybrid functional, B3LYP, and Def2TZVP basis set.
NMR and FTIR spectra confirmed ligand formation and coordination of the metal through imine and carbonyl groups.
A single crystal was obtained only for L1 after several attempts.
Conductivity data, UV-visible spectra, and magnetic moment values of the complexes were all in favor of the square planar geometry.
All the synthesized compounds displayed satisfactory antimicrobial potency, with L2 and CuL1L2 showing superior activity against Pseudomonas flurescens and Candida albican, compared to the standard drug (Chloramphenicol).
The DFT results not only corroborated the experimental findings but also provided valuable insights into the mechanism of action of the synthesized compounds.
KEY WORDS: Antimicrobial resistance, DFT, Homoleptic and heteroleptic copper(II) complexes, Hydrazone Schiff base, p-toluic acid hydrazide
Bull.
Chem.
Soc.
Ethiop.
2026, 40(10), 2097-2114.
DOI: https://dx.
doi.
org/10.
4314/bcse.
v40i10.
4 .
Related Results
Synthesis, Characterization, Chemosensing, And Antimicrobial Studies of Schiff Base Derived From 2-Pyridinecarboxaldehyde and Its Mn (II) And Ni (II) Complexes
Synthesis, Characterization, Chemosensing, And Antimicrobial Studies of Schiff Base Derived From 2-Pyridinecarboxaldehyde and Its Mn (II) And Ni (II) Complexes
A suitable quantity of 2-nitroaniline and 2-pyridinecarboxaldehyde were refluxed to create the Schiff base. Mn(II) and Ni(II) complexes were created using the synthetic Schiff base...
SYNTHESIS, GRAVIMETRIC ANALYSIS AND ANTIMICROBIAL STUDIES OF TRANSITION METALS (Cu(II), Zn(II)) COMPLEXES OF SCHIFF DERIVED FROM 2-HYDROXY-1-NAPHTHALDEHYDE AND 2-AMINO-3-METHYLPYRIDINE
SYNTHESIS, GRAVIMETRIC ANALYSIS AND ANTIMICROBIAL STUDIES OF TRANSITION METALS (Cu(II), Zn(II)) COMPLEXES OF SCHIFF DERIVED FROM 2-HYDROXY-1-NAPHTHALDEHYDE AND 2-AMINO-3-METHYLPYRIDINE
The interaction between 2-hydroxy-1-naphthaldehyde with 2-amino-3-methylpyridine give an orange- yellow Schiff base and its metals complexes of Cu (II) and Zn (II) were green and d...
Ensemble density-functional theory : an ensemble perspective to target excited states and to palliate infamous deficiencies of standard ab initio methods
Ensemble density-functional theory : an ensemble perspective to target excited states and to palliate infamous deficiencies of standard ab initio methods
La théorie de la fonctionnelle de la densité d'ensemble : une alternative pour décrire les états excités et pour pallier aux limitations des méthodes ab initio standard
...
Ionic complexes of biodegradable polyelectrolytes
Ionic complexes of biodegradable polyelectrolytes
Biopolymers are polymers produced by living organisms. A more broad classification would embrace also those polymers synthesized from renewable sources which are able to display bi...
An efficient synthetic route, characterization and antimicrobial evaluation of Co(II), Ni(II), Cu(II) and Zn(II) Schiff base complexes
An efficient synthetic route, characterization and antimicrobial evaluation of Co(II), Ni(II), Cu(II) and Zn(II) Schiff base complexes
ABSTRACT. The synthesis of Schiff base compound derived from 2-hydroxy-3-methoxybenzaldehyde and o-phenylenediamine via solvent-assisted mechanochemical synthesis in the presence o...
Energy-Efficient Synthetic Method, X-Ray Diffraction Analysis and Thermal Decomposition of Cobalt (II) and Nickel (II) Schiff Base Complexes Derived from 2-Aminobenzothiazole
Energy-Efficient Synthetic Method, X-Ray Diffraction Analysis and Thermal Decomposition of Cobalt (II) and Nickel (II) Schiff Base Complexes Derived from 2-Aminobenzothiazole
A Schiff base was synthesized from the condensation reaction of 2-hydroxybenzaldehyde and 2-aminobenzothiazole via energy-efficient liquid-assisted mechanochemical synthesis (LAG)....
Schiff Bases and Their Metal Complexes: Synthesis, Structural Characteristics and Applications
Schiff Bases and Their Metal Complexes: Synthesis, Structural Characteristics and Applications
The development of Schiff base was a major step forward in the area of coordination chemistry. Schiff bases, a class of organic compounds, carry the imine or azomethine (>C=N–) ...
Pharmacological Investigations, Synthesis, and Spectral Analyses of Newly Synthesized Potentially Bioactive Ethyl Silicon (IV) Schiff Base Complexes
Pharmacological Investigations, Synthesis, and Spectral Analyses of Newly Synthesized Potentially Bioactive Ethyl Silicon (IV) Schiff Base Complexes
Schiff bases, an active biological moiety, possess diverse pharmacological activities. Here, ethyl silicon (IV) complexes are formed by reacting ethyl silicon alkoxides with Schiff...