Pharmacological Investigations, Synthesis, and Spectral Analyses of Newly Synthesized Potentially Bioactive Ethyl Silicon (IV) Schiff Base Complexes

Schiff bases, an active biological moiety, possess diverse pharmacological activities. Here, ethyl silicon (IV) complexes are formed by reacting ethyl silicon alkoxides with Schiff base. The Schiff bases and their ethyl silicon (IV) complexes were characterized physically as well as by using spectral characterization techniques, including infrared spectroscopy and multinuclear NMR (1H, 13C, and 29Si-NMR). Later, these Schiff bases and their ethyl silicon (IV) complexes were compared for various biological activities. In antibacterial activity, new ethyl silicon (IV) Schiff base complexes inhibited the growth of all the four selected bacteria. In all the complexes the zone of inhibition was found to be dose dependent, i.e. with the increase in the concentration the zone of inhibition increased. The maximum zone of inhibition for the bacterium B. subtilis, S. aureus, E. Coli, and S. abony, 1c showed maximum zone of inhibition with (80%), (69.69%), (91.67%), and (50%), percent inhibition at 10mg/ml. Pharmacological activities show an increase in the number of organic groups as well as in the coordinating environment of silicon. All compounds exhibited antioxidant, anti-inflammatory, and anti-diabetic activities, but the ethyl silicon (IV) Schiff base complexes demonstrated superior activities relative to the Schiff base.