PROCEEDINGS OF THE AUSTRALASIAN SOCIETY OF CLINICAL AND EXPERIMENTAL PHARMACOLOGISTS

14th Annual Meeting, December 1980, Canberra1. Effect of dexamethasone on pineal β‐adrenoceptors. C. A. Maxwell, A. Foldes, N. T. Hinks and R. M. Hoskinson2. A clinicopathological study of lithium nephrotoxicity. R. G. Walker, P. Kincaid‐Smith and B. M. Davies3. Specific assay and initial pharmacokinetics of a new vasodilator antihypertensive, endralazine. P. A. Reece, I. Cozamanis and R. Zacest4. The effects of an histamine H2‐receptor agonist (Impromidine, SK & F 92676) on the general and cardiac haemodynamics of the intact dog. G. M. Maxwell5. Formaldehyde‐induced fluorescence of bronchodilator drugs. Lesley J. Bryan and Stella R. O'Donnell6. Cardiovascular effects of CL 126(2‐methoxy‐4‐methyl‐N‐isopropylphenyl ethanolamine) in anaesthetized dogs. Evelyn Yeoh, L. G. Letts, L. B. Cobbin and L. R. Williams*7. Inhibition of microsomal mixed function oxidase activity by cimetidine. R. Drew, J. Rowell and J. J. Grygiel8. Potentiation of the anticoagulant effect of warfarin by sulphinpyrazone. D. J. Birkett, J. O. Miners, S. Wanwimolruk, T. Foenander and A. Gallus9. Diflunisal–probenecid codisposition: Michaelis Menten kinetics with competitive inhibition. P. J. Meffin*, J. R. Veenendaal* and P. M. Brooks10. Naproxen disposition in renal dysfunction. J. R. Veenendaal*, P. M. Brooks and P. J. Meffin*11. The effect of combinations of aspirin and other non‐steroidal anti‐inflammatory drugs (NSAIDs) on inflammatory response assessed by polyurethane sponge implantation in rats. P. M. Brooks*, B. Vernon Roberts, B. Manthey and R. Garrett12. In vivo inhibition of anaphylactically‐released histamine by fenoterol. A. G. Stewart and M. R. Fennessy13. Pharmacological modification of Δ9‐tetrahydrocannabinol (Δ9‐THC) induced hypothermia in the rat. A. J. M. Verberne, S. J. Lewis and M. R. Fennessy14. Effects of activation of prejunctional β‐adrenoceptors during differing amounts of prejunctional α‐adrenoceptor activation. M. J. Rand and H. Majewski15. Effects of clonidine on responses to sympathetic nerve stimulation in the autoperfused hindquarters of the pithed rat. I. C. Medgett and M. J. Rand16. Modulation of sympathetic transmission in guinea‐pig atria by transmitter noradrenaline under physiological conditions. M. W. McCulloch, I. Sutton, D. F. Story and M. J. Rand17. Comparative actions of prostacyclin and thromboxane A2‐like agonist, U‐46619 on cardiac chemoreflexes in the dog. P. N. Nolan, Denise E. May and Janina Staszewska‐Barczak18. Propranolol per se does not alter cyclic nucleotide levels in vascular smooth muscle or noradrenergic nerves. Zainuddin Merican and M. W. Nott19. The effects of α‐adrenoceptor agonists and antagonists on the release of 3 H‐adrenaline from a rabbit isolated adrenal preparation. A. R. Collett, M. J. Rand and D. F. Story20. Structure–activity relationships of a series of 6,7‐dihydroxytetrahydroisoquinoline derivatives at β‐adrenoceptors of guinea‐pig atria. M. W. Nott, M. Sunbhanich, D. Beaumont* and R. D. Waigh*21. Nomifensine pharmacokinetics, cardiovascular effects and clinical response. I. M. Mclntyre, T. R. Norman and G. D. Burrows22. Anti‐inflammatory/anti‐arthritic effect of percutaneously applies copper salicylates in DMSO. M. W. Whitehouse, S. J. Beveridge* and W. R. Walkerd̊23. Identification of a probable nephrotoxic metabolite of phenacetin in urine of rats and man. S. McLean*, N. W. Daviesd̊, H. Watson*, W. A. Favretto* and J. C. Bignalld̊24. A selective β1, ‐adrenoceptor antagonist, ICI 89963. Stella R. O'Donnell and H. M. S. Snow25. Demonstration of β1 ‐ and β2‐adrenoceptors in the pulmonary artery of the rat. Janet C. Wanstall and Stella R. O'Donnell26. Extraneuronal uptake in non‐vascular smooth muscle cells. Julianne J. Cole and Stella R. O'Donnell27. Electrophysiological studies of the muscle plasma membrane in malignant hyperpyrexia. G. J. Galloway, * J. C. Bomstein and M. A. Denborough28. The effects of prostaglandin E2 on contractility and cyclic AMP levels of guinea‐pig tracheal smooth muscle. B. R. Creese and M. A. Denborough29. Mechanism of phenoxybenzamine potentiation of sympathetic stimulation, unrelated to presynaptic ‘clonidine’ receptors. J. A. Angus, A. Nakashima and P. I. Korner30. The influence of infusion time on the duration of effective plasma concentrations of two‐compartment model drugs. D. J. Morgan and K. Raymond*31. Prostaglandins and the responses to mild and severe renal ischaemia in conscious dogs. W. P. Anderson and D. J. Casley32. Conversion of MHPG to VMA in man. P. A. Blombery, I. J. Kopin, E. K. Gordon, S. P. Markey and M. H. Ebert33. Placental transfer of the H2‐receptor antagonist ranitidine (R) in the pregnant sheep. G. W. Mihaly, D. J. Morgan*, A. W. Marshall, S. Cockbain, R. A. Smallwood and K. J. Hardy, Gastroenterology Unit34. Theophylline pharmacokinetics in patients from a geriatric hospital: influence of cigarette smoking. D. D. Thorsborne‐Palmer*, P. W. Trembathd̊, B. Jarrott*, J. J. Hammond‡ and D. Prinsley‡35. Evaluation of the provision of rapid drug plasma assays in an out‐patient neurology clinic. R. Fullinfaw, R. Tuckett, J. Marty*, P. Trembath and J. King36. A comparison of the effects of diazoxide, chlorothiazide, ethacrynic acid and frusemide on human vascular smooth muscle. J. S. L. Mok and R. F. W. Moulds37. Classification of β‐adrenoceptors in isolated rat trachea. P. J. Henry, K. M. Lulich and J. W. Paterson38. Intestinal metabolism of pentazocine in the rabbit. R. D. Anderson and K. F. Ilett39. Effects of desmethylimipramine on the disposition of 5‐hydroxytryptamine, β‐phenyl‐ethylamine and propranolol in rat lung. K. F. Ilett, H. E. Barber and R. F. Minehin40. Prednisolone pharmacokinetics in children with nephrotic syndrome: studies in relapse and remission. J. M. Potter and G. D. Bower*41. Evaluation of insulin‐liposomes in diabetic rats. G. M. Shenfield and J. C. Hill42. Plasma theophylline assay service for out‐patients. J. W. Paterson, R. H. Yellin, K. F. Ilett and B. W. Madsen43. Dose‐response study of intravenous rimiterol in asthmatic patients. J. W. Paterson, V. Martyn* and R. A. Taralad̊44. Ethanol‐ and isoprenaline‐induced responses of pig peripheral lung strip. R. G. Goldie, J. L. Wale and J. W. Paterson45. Stimulation of myocardial prostacyclin biosynthesis by increased arterial pressure. G. J. Dusting and R. D. Nolan, University of Melbourne46. Antagonism of vascular actions of a thromboxane‐like analogue by meclofenamate. M. Purchase and G. J. Dusting, University of Melbourne47. Actions of 4‐methyl‐2‐aminopyridine on neuromuscular transmission and contractility in isolated skeletal muscle‐nerve preparations. N. Kiloh, A. L. Harvey and W. E. Glover48. Differential effects of cholinergic agonists and antagonists in lines of rats genetically selected for sensitivity to the anticholinesterase, DFP. D. H. Overstreet, R. W. Russell, R. A. Netherton, M. Messenger, S. C. Helps and W. Kerni49. Influence of ovariectomy on the sex‐dependent effects of DFP and other cholinergic drugs in rats. R. A. Netherton, W. Kerni, D. H. Overstreet and R. W. Russell50. Inhibition of histamine‐induced dye‐leakage by rimiterol in guinea‐pig skin. Robyn A. Braun and Stella R. O'Donnell51. Cefoxitin clearance studied by physiological and compartment modelling techniques. L. E. Mather, W. B. Runciman and A. H. Ilsley52. Organ extraction and pharmacokinetics of chlormethiazole in patients undergoing angiographic procedures. L. E. Mather, W. B. Runciman, and A. H. Ilsley53. Effects of the neutral‐base transition of human serum albumin on specific drug‐binding sites. D. J. Birkett and S. Wanwimolruk54. Protein binding of a new, basic non‐steroidal anti‐inflammatory drug (NSAID), GP 53,633, and its major metabolite. S. Wanwimolruk*, P. M. Brooksd̊ and D. J. Birkett*55. The effects of cimetidine on theophylline clearance in rat. J. J. Grygiel, R. Drew, J. 0. Miners, J. Rowell, J. O. Willoughby* and D. J. Birkett56. Effects of cigarette smoking on theophylline clearance and metabolism. J. J. Grygiel and D. J. Birkett57. Effects of central noradrenergic and serotonergic neurons on the control of heart rate through vagal mechanisms. G. A. Head and P. I. Korner58. Interaction between cimetidine and theophylline in smokers and non‐smokers. J. O. Miners, J. J. Grygiel, R. Drew and D. J. Birkett59. Clinical usefulness of urinary drug screening in hospital practice. R. W. Bury and M. L. Mashford60. Effect of cimetidine on disposition of orally administered chlormethiazole. R. G. Shaw, R. W. Bury, M. L. Mashford, K. J. Breen and P. V. Desmond61. Self‐poisoning with drugs in Newcastle, NSW, 1976–79. A. J. Smith, P. MacAskill, R. L. Elliott and J. B. Myers, Faculty of Medicine62. Different contributions of inflammatory mediators to the increased vascular permeability induced by silver nitrate in cutaneous, subcutaneous and joint tissues of the rat. M. C. Fyfe and L. A. Chahl*63. Identification of β2 ‐adrenoceptors in bovine cerebral cortex microvessels by radioligand assay. A. J. Culvenor and B. Jarrott64. Labelling of α2 ‐adrenoceptors in rat cerebral cortex with 3H‐guanfacine. R. J. Summers, B. Jarrott and W. J. Louis65. The β‐adrenoceptor selectivity of atenolol, ICI 118,551 and α‐methylpropranolol in anaesthetized guinea‐pigs. Karin Walduck and Stella R. O'Donnell66. The effects of some anti‐inflammatory drugs on oxygen‐free radicals with reference to inflammatory tissue damage. W. H. Betts and L. G. Cleland67. The role of bradykinin in the hypotensive response to captopril. M. G. Straw, M. Yasujima, C. I. Johnston and P. G. Matthews68. Improvement in cardiac function and evidence of inhibition of the angiotensin‐aldosterone system after captopril treatment in patients with refractory cardiac failure. I. M. Denham, B. P. McGrath and C. I. Johnston69. The effect of tricyclic antidepressant metabolites on the uptake of serotonin by human blood platelets. T. R. Norman, G. D. Burrows and H. Cheng70. Human platelet aggregation in response to blood concentrations of multiple agonists: possible implications. H. A. Culliver and N. G. Ardlie71. The fibrin network: evidence for an ordered structure. I. A. Ferguson, G. A. Shah, N. G. Ardlie* and D. P. Dhall72. Constrictor responses to noradrenaline in guinea‐pig lung strips. A. J. Turner, J. L. Black and J. P. Seale73. Responses of human peripheral lung strips to stimulation of a‐adrenoceptors. J. L. Black, A. J. Turner and J. Shaw74. Selective antagonism of inhibitory responses to ATP and non‐adrenergic, non‐cholinergic nerve stimulation in the guinea‐pig taenia coli by nucleotide pyrophosphatase. D. Satchell75. TMB‐8‐induced hyperreactivity in malignant‐hyperpyrexia‐susceptible swine skeletal muscle. J. S. Sullivan and M. A. Denborough76. 3H‐Spiperone binding to membranes from the nucleus accumbens of the rat. P. M. Beart and D. McDonald77. Evidence for heterogeneity of post‐junctional α‐adrenoceptors from studies in guinea‐pig capsular splenic smooth muscle. G. A. McPherson and R. J. Summers78. Characteristics of 3 H‐strychnine binding in the ventral tegmentum of the rat. A. L. Gundlach and P. M. Beart79. Comparison of the effect of four different β‐adrenoceptor antagonists on pentylenetetra‐zole‐induced seizures. J. Papanicolaou, F. J. E. Vajda and W. J. Louis80. The effects of initial and chronic doses of prazosin in mild hypertension. M. Dynon, S. N. Anavekar, B. Jarrott and W. J. Louis81. The platform technique of REM sleep deprivation in rats: apomorphine subsensitivity and stress. P. Harris and D. H. Overstreet82. Sodium valproate as adjuvant treatment in status epilepticus. F. J. E. Vajda, J. Currie and R. Beran83. Survey of design and analysis of controlled trials of non‐steroidal anti‐inflammatory drugs. J. Vallance, P. J. McNaught, L. J. Hills*, I. Hamann and G. D. Champion84. Influence of thyroid state upon cardiovascular responses mediated by muscarinic receptors. E. J. N. Ishac and J. N. Pennefather85. Compliance with pressurized aerosol therapy. E. Chryssidis, D. B. Frewin and P. A. Frith*86. The relative bioavailability of acetylsalicylic acid from a soluble and an enteric‐coated preparation, and the effect of each on platelet function. F. Bochner*, M. J. Elms, L. M. Ross‐Lee*, B. Cham* and I. H. Bunce87. The duration of regional vascular and hormonal changes following meclofenamate in the conscious rabbit. R. A. Banks, L. J. Beilin and L. Davidson88. Changes in binding of 3H‐ADTN and 3 H‐spiroperidol in rat striatal membranes after pre‐exposure to dopamine agonists in vitro. D. F. H. Dougan and D. N. Wade89. A model of portal‐systemic shunting in the rat. C. G. Meredith and D. N. Wade90. Accumulation of α‐methylated phenolamines in rat brain after chronic administration of d‐amphetamine. P. Duffield, D. Dougan, D. Wade and A. Duffield*91. Decline in steady‐state serum levels of salicylate in normal subjects ‐ preliminary results. R. O. Day, D. E. Furst*, S. H. Dromgoole*, B. R. Day and H. E. Paulus*92. Phenytoin, phenobarbitone and carbamazepine elimination kinetics in overdosed patients. P. M. Chinwah, D. N. Wade and K. M. Williams93. Postnatal development ofα1‐ and α2 ‐adrenoceptors. M. J. Morris and E. A. Woodcock94. HPLC determination of tetrabenazine and its hydroxymetabolite in plasma. M. S. Roberts*, H. Watson, S. McLean and K. S. Millingen *95. Modification of mediator release from human lung by lipoxygenase inhibitors. C. L. Armour, J. M. Hughes, J. P. Seale and D. M. Temple96. Cardiovascular effects of maprotiline in the anaesthetized dog. R. Mehanna and L. B. Cobbin97. The effects of ethanol on the protein environment in human erythrocyte membranes. R. Laverty, B. J. Logan and B. M. Peake*98. The effect of metoclopramide on the absorption of long‐acting propranolol. P. J. Renshaw, B. G. Charles, P. J. Ravenscroft and J. Kay99. A comparison of the bioavailability of theophylline liquids and tablets. P. J. Ravenscroft, B. G. Charles, J. Sligo and F. Bochner*100. Determination of unbound fraction of disopyramide in plasma using a rapid ultrafiltration method. R. L. G. Norris, J. T. Ahokas and P. J. Ravenscroft101. Effects of theophylline and caffeine on liver microsomal drug metabolizing mono‐oxygenase in genetically AHH responsive and non‐responsive mice. J. T. Ahokas, O. Pelkonen*, P. J. Ravenscroft and B. T. Emmerson102. Involvement of the tryptaminergic system in the anorexia induced by Δ9‐tetrahydrocannabinol in the rat. D. A. Taylor103. The effect of captopril on plasma histamine. K. M. Taylor and D. N. Sharpe104. Etomidate enhancement of GABA binding to rat brain synaptosomal membranes. M. Willow105. Beta‐adrenoceptor selectivity in anaesthetized cats. K. F. S. Kiyingi, L. G. Letts and D. M. Temple106. The effect of naloxone on ethanol‐induced impairment of human psychomotor performance. J. Perl, K. D. Bird*, J. L. Black, G. B. Chesher, J. Craig, G. A. Starmer and R. K. C. Teo107. Differential distribution of receptors for morphine and Met5‐enkephalinamide in the dorsal horn of the cat. S. M. Johnson, A. W. Duggan and C. R. Morton108. Direct HPLC measurement of ester and ether glucuronides in biological fluids. J. R. Veenendaal*, P. M. Brooks and P. J. Meffin*109. A study of medicine bottle opening in arthritis. S. Mugford, F. May, M. Dougan* and P. M. Brooks*110. Cardiovascular responses following intracisternal administration of histamine, noradrenaline and clonidine in the anaesthetized rat. G. A. Eddie, S. J. Lewis, M. R. Fennessy and W.J. Lang111. Development of tolerance to Δ9‐tetrahydrocannabinol (Δ9‐THC) induced reduction in brain regional histamine concentrations in the rat. M. R. Fennessy, A. J. M. Verberne, S. J. Lewis and D. A. Taylor112. Effects of exposure of rats to cigarette smoke on autacoid metabolism in the isolated lung. A. L. A. Boura, J. M. Atkinson, Mary P. Rechtman and W. A. W. Walters113. Effects of angiotensin, bradykinin and vasopressin on resting rate and on sympathetic stimulation in isolated guinea‐pig right atria. A. Nakashima, J. A. Angus and C. I. Johnston*114. Serotonin antagonists and the action of ergometrine in dog coronary artery. R. M. Brazenor and J. A. Angus115. Computer based methods of estimating the antagonist dissociation constant Kg and the use of the ‘Clark’ plot. J. Gipps, R. M. Brazenor and J. A. Angus116. Betaj‐adrenoceptor‐mediated vasodilatation in the cat. E. Malta, G. A. McPherson, C. Maccarrone and C. Raper117. The colorimetric determination of thiocyanate in plasma. N. Grgurinovich118. Serum level monitoring survey of a new slow‐release theophylline preparation. M. A. Butcher, G. E. Marlin, J. A. Klumpp and P. J. Thompson (introduced by G. E. Marlin)119. Evaluation of a radioreceptor assay for (–)propranolol in plasma. G. P. Jackman, A. Bobik, G. Jennings and A. J. McLean120. Constrictor mechanisms of ergotamine in rabbit common carotid arteries. I. M. Adams and E. J. Mylecharane121. Rapid determination of metformin in plasma and urine by high‐performance liquid chromatography. B. G. Charles, P. J. Ravenscroft and N.W. Jacobsen*122. Method for measuring the in vitro metabolism of theophylline by HPLC and scintillation counting. J. T. Ahokas, P. J. Ravenscroft and B. T. Emmerson123. Some effects of acute and chronic morphine treatment on jejunal fluid transport. M. K. Lee and I. M. Coupar124. Contribution of gut and liver to presystemic elimination of drugs in man. R. F. Minchin and K. F. Ilett125. Structural requirements of chlorphentermine‐binding inhibitors in rat lung subcellular fractions. R. F. Minchin and B. W. Madsen*126. Pharmacokinetics of metrizamide during lactation. K. F. Ilett, L. P. Hackett, C. C. McCormick* and J. W. Paterson127. 3 H‐catecholamine transport in pig peripheral lung. R. G. Goldie and J. W. Paterson128. Alpha‐adrenoceptors in rat kidney studied by 3H‐clonidine and 3H‐prazosin binding. R. J. Summers and G. A. McPherson129. Pharmacokinetics of an aromatic retinoid, RO 10‐9359, and its metabolites RO 10‐1670 and RO 13‐7652 in patients with Darier's disease. S. Ray, E. Begg and D. Wade130. The influence of smoking on the distribution of gold in blood. T. M. Haavisto, G. D. Champion, G. G. Graham and P. J. McNaught