Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists

8th Annual Meeting, 27–29 November, 1974, Sydney 1. Effect of alprenolol on work tolerance in hypertension and ischaemic heart disease. B. Lake 2. Motor skill performance measures in drug and drug‐alcohol interaction research. A. A. Landauer, D. A. Pocock and F. W. Prott G. Singer 3. NAB‐365—is it a selective β2‐adrenoreceptor agonist? Stella R. O'Donnell 4. The effect of phenoxybenzamine on the diffusion of exogenous noradrenaline into the lumen of the rabbit ear artery. D. A. S. Parker and I. S. de la Lande 5. Actions of levodopa on the cat soleus muscle. M. W. Nott 6. The effect of a chromatographically pure sample of adenosine tetraphosphate on blood platelets. Fylia Penglis 7. The role of the liver in the clearance of levodopa. G. Graham, P. T. Mearrick and D. N. Wade 8. The clearance of levodopa from plasma. P. T. Mearrick, G. G. Graham, D. N. Wade and J. L. Morris 9. Clinical pharmacology and efficacy of benorylate in patients with rheumatoid arthritis. G. D. Champion, R. O. Day, P. D. Paull, G. G. Graham, M. S. Owen and A. L. Haski 10. The effect of disodium cromoglycate on human psychomotor performance, alone and in combination with ethanol. H. M. Franks, G. A. Starmer, W. J. Hensley, W. A. Crawford, V. R. Hensley and R. Teo 11. The interaction of ethanol and Δ9‐tetrahydrocannabinol in man. Effects on psychomotor skills. G. B. Chesher, H. M. Franks, G. A. Starmer, D. M. Jackson, W. J. Hensley, V. R. Hensley and R. Teo 12. Effect of Δ9‐tetrahydrocannabinol on body temperature and brain monoamines in the rat. D. A. Taylor and M. R. Fennessy 13. The effect of xylitol on the metabolic equilibrium and energy status in normal rabbit liver. J. Bostrom, J. E. Ray, D. N. Wade and K. G. Rienits 14. Separation of high and low Ca++ affinity (Mg+++ Ca++)‐ATPases in human erythrocytes and their relationship to active Ca transport. B. D. Roufogalis and E. E. Quist D. N. Wade 15. Effect of clonidine on self‐stimulation behaviour of rats with electrodes within the medial forebrain bundle of the lateral‐hypothalamus. G. E. Hunt, G. B. Chesher* and D. M. Atrens 16. The effect of methylhyoscine on intracranial self‐stimulation in rats. F. Becker, D. M. Atrensd̊ and G. B. Chesher 17. Is isometric exercise useful for testing anti‐anginal drugs? G. Nyberg 18. The inhibitory effects of anti‐inflammatory drugs on the degradation of hyaluronate by rheumatoid synovial fluid polysaccharidases. R. W. Stephens, P. Ghosh and T. K. F. Taylor L. B. Cobbin 19. Effect of equi‐antihypertensive doses of mefruside and cyclopenthiazide on serum electrolytes, uric acid and glucose tolerance in hypertensive patients. Hendrika J. Waal‐Manning 20. Individual titration of intravenous diazoxide therapy in patients with severe hypertension. L. B. Jellett, M. S. Dye, A. M. Michelakis and J. A. Oates 21. The relationship of plasma levels of pindolol to effects on blood pressure, plasma renin and catecholamines in hypertensive patients. S. N. Anavekar, W. J. Louis, T. O. Morgan, A. E. Doyle and C. I. Johnston 22. Metabolism of methylphenobarbitone in man. F. Bochner, W. D. Hooper, G. A. Smith, M. J. Eadie and J. H. Tyrer 23. The blocking action of propranolol on responses of isolated vas deferens to electrical stimulation. I. E. Hughes and Barbara Kneen L. B. Jellett 24. The effects of 3‐hydrazino‐6‐[N,N‐bis (2‐hydroxyethyl) amino]‐pyridazine dihydrochloride (L6150) on the general and coronary haemodynamics and metabolism of the intact animal. G. M. Maxwell 25. The effects of some α‐ and β‐adrenoceptor agonists in the cat. R. E. Dunstan, R. A. Buistd̊, L. B. Cobbin, D. M. Temple and L. R. Williams 26. Histamine sensitivity of cat lung in vitro: a difference in relaxing efficacy between isoprenaline and aminophylline. H. W. Mitchell and M. P. Sparrow 27. The absorption and elimination of carbamazepine in man. W. D. Hooper, L. M. Cotter, M. J. Eadie & J. H. Tyrer 28. Effects of the angiotensin antagonist P113 in chronic experimental renal hypertension. P. J. Fletcher, J. A. Angus, J. R. Oliver and P. I. Korner 29. Cardiovascular toxicity of tricyclic antidepressant drugs. Prasan Dhumma‐Upakorn and L. B. Cobbin 30. Intestinal conjugation of isoetharine. R. H. Briant L. B. Cobbin 31. Comparison of the effects of (—)‐isoprenaline, orciprenaline, terbutaline and Me506 on cat soleus muscle contractility, heart rate, and airways resistance. E. Malta and K. Bohmer 32. Some β‐receptor‐mediated actions of Sm220C1 in the cat and guinea‐pig. K. Bohmer and C. Raper 33. Catecholamine‐metabolizing enzymes in human adrenal glands and phaeochromocytomas. B. Jarrott, L. Tomlinson and W. J. Louis 34. Locomotor activity after different doses of dexamphetamine in rats pretreated with 6‐hydroxydopamine. R. Laverty and Min‐Chu Liew 35. Decrease in isoprenaline‐induced formation of cyclic adenylic acid in heart after prolonged exposure to salbutamol or isoprenaline. S. V. Hopkins 36. Effects of levodopa metabolites at a dopamine receptor: a pharmacological basis for the ‘on‐off’ effect in Parkinson's disease. D. F. H. Dougan, D. N. Wade and P. T. Mearrick 37. The effects of chlorphentermine on drug metabolism in rat lung and liver. K. F. Ilett L. B. Jellett 38. The effects of neurotransmitters and nerve stimulation upon contractility of the guinea‐pig ovary in vitro. J. N. Pennefather 39. Renal hypertension and β‐adrenoceptor blockade in rats. D. R. Lee 40. α‐Adrenoreceptor blocking activity of tricyclic antidepressant compounds. A. B. Glover, M. W. McCulloch and D. F. Story 41. An investigation of the antimuscarinic effect of gallamine in isolated guinea‐pig atria. A. L. Clark and F. Mitchelson 42. Interaction of pimozide with prejunctional dopamine receptors in the rabbit ear artery. M. J. Rand, W. Hope, M. W. McCulloch and D. F. Story 43. Chemical basis of schedule‐induced polydipsia. G. Singer and M. J. Wayner 44. Testing of β‐adrenoceptor antagonists in angina pectoris. G. Nyberg 45. Behavioural effects of parachlorophenylalanine—an inhibitor of 5‐hydroxytryptamine synthesis. A. E. McQueen, W. J. Louis and G. Singer 46. Interaction between lithocholic acid and erythromycin estolate/stearate producing hepatotoxicity in rabbits. B. G. Priestly and R. Drew 47. Hepatic microsomal drug metabolism in rabbits treated with lithocholic acid and erythromycin estolate/stearate. R. Drew and B. G. Priestly 48. Bioavailability of enteric coated aspirin. P. D. Paull, R. O. Day, G. G. Graham and G. D. Champion 49. Behavioural effects of prenatal exposure to imipramine in the rat. I. R. Coyle 50. A critical evaluation of drug interactions in man: the effect of tricyclic antidepressants on dicoumarol elimination. S. M. Pond, G. G. Graham and D. N. Wade 51. A study of blood lead levels in the Sydney metropolitan area. S. J. Mencel and R. H. Thorp 52. An experimental model in the pig for the study of liver drug metabolism. Margaret Rose and J. M. Ham 53. Pharmacokinetics of prazosin, a new antihypertensive compound. Ian S. Collins and Pat Pek 54. Pharmacokinetics of prazosin in man. A. J. Wood 55. A double blind factorial trial of pindolol and hydrochlorothiazide in hypertension. A. Bune, J. P. Chalmers, P. I. Korner, J. Steiner, D. J. Tiller, J. B. Uther, M. West and L. M. Wing 56. Modification of adrenergic mechanisms in the isolated rabbit ear artery by reduction of pH. R. L. Leslie, G. J. Dusting and M. J. Rand 57. Independence of gastrin and histamine receptors in the lower oesophageal sphincter of the monkey and possum. D. J. de Carle and W. E. Glover 58. Interactions between prostaglandins and anti‐inflammatory drugs on respiratory tissue. Diana M. Temple, Heather J. McIntyre and I. D. Smith 59. The characterization of two specific drug binding sites on human serum albumin. D. N. Wade, G. Sudlow and D. J. Birkett 60. Tremorogenic effects of harmaline and harmine: interference with a tryptaminergic mechanism? D. Lodge and P. M. Headley G. A. R. Johnston 61. Histamine release by guanethidine in the rabbit. J. A. Angus and P. I. Korner