EXPERIMENTAL ASSESSMENT OF THE ACUTE TOXICITY OF "KUBAZOL" – SOLUTION FOR EXTERNAL APPLICATION BASED ON BIRCH TAR

Laboratory studies were conducted to determine the acute toxicity of the veterinary drug "Kubazol" on white rats. The drug "Kubazol" - a veterinary drug (spray for external use, solution) contains birch tar in its composition. Intended for the treatment and prevention of lesions of the skin (wounds, dermatitis, eczema), claws (injuries, superficial panaritium), hooves and hooves (foot rot, etc.) in dogs, wild pigs, wild birds and sports horses. According to the results of determining the parameters of the acute toxicity of the drug "Kubazol" (spray for external use, solution), in the case of a single intragastric administration, the LD50 for male rats is 7328.87±878.80 mg/kg of body weight, which allows us to classify it as toxic up to V class - practically non-toxic substances (LD50 5001-15000 mg/kg), and according to the degree of danger - up to IV class - low-hazard substances (LD50 > 5000 mg/kg). According to the results of toxicological studies of the veterinary drug "Kubazol" (spray for external use, solution), the LD50 indicator could not be calculated, since the death of laboratory animals was not detected within 14 days after application to the skin of rats. At the same time, the maximum dose of the drug "Kubazol (spray for external use, solution) applied to the skin of rats (based on the absolute weight of the drug) was 15,000.0 mg/kg of body weight, which allows the drug to be classified according to the degree of danger to the IV class - low-hazardous substances (LD50Сut>2500.0 mg/kg of body weight). Further studies will be the next stage of pre-registration tests aimed at studying the chronic toxicity of "Kubazol", which is mandatory material in the section "Studies on safety and residues" of the dossier for this drug.