Determination of the carcinogenicity of a preparation for external use based on birch tar in white mice

The article presents the results of the study of the carcinogenicity of the veterinary drug “Kubazol” on white rats. This work aims to determine the carcinogenic potential of the drug for external use based on birch tar in an experimental model using white mice. This approach objectively assesses the drug's safety before its further use in veterinary clinical practice. The drug “Kubazol” is a spray for external use solution. 1 ml of the drug contains the active ingredient: birch tar – 40.0 mg – excipients: ethyl acetate, polybutyl methacrylate. The veterinary drug is used for dogs: treatment of animals for skin lesions (wounds, dermatitis, eczema), claw lesions (superficial panaritium, etc.), and postoperative treatment of claws. Horses (sports): treating animals for hoof diseases (corneal arrow suppuration, superficial panaritium), postoperative treatment of hooves. As a result of the conducted studies, it was found that the drug “Kubazol” (spray for external use, solution) under the conditions of 5-day application to the skin of white mice in doses of 1.0 and 10.0 ml/kg of body weight did not show carcinogenic effects (during microscopic studies, the proportion of polychromatophilic erythrocytes did not have significant deviations from each other and was 0.133–0.150 %, which was within the normal range of 0.2 %). The study of the drug's carcinogenicity for external use based on birch tar opens up new directions for further study of its properties and potential risks. Based on the results obtained, clinical studies are promising. The transition to animal testing considers the data obtained on experimental models for the final confirmation of the drug's safety.