Formulation and Evaluation of Ethosomal Gel from Syzygium Cumini for Anti-Acne Activity

The present work was undertaken to formulate and analyze an ethosomal gel using Syzygium cumini seed extract for its potential anti-acne efficacy. Syzygium cumini (Jamun) is a well-known medicinal plant rich in bioactive elements such as anthocyanin’s, phytosterols, flavonoids, and polyphenols, containing antibacterial, anti-inflammatory, and antioxidant effects. Jamun seeds were gathered, dried, ground into a powder, and then Soxhlet extracted using ethanol. The resulting extract was integrated into ethosomes, which are soft lipid vesicles made of phospholipids, ethanol, and water, known for improving skin penetration. The ethosomal suspension was prepared by the hot method and subsequently incorporated into a Carbopol gel base to obtain a smooth topical formulation. Phytochemical screening confirmed the presence of key active constituents. The pH, viscosity, spread ability, homogeneity, and drug content of the prepared ethosomal gel were assessed. The formulation's anti-acne potential was evaluated using an in vitro protein denaturation assay. The findings showed that the ethosomal gel had high consistency and stability, as well as acceptable physicochemical characteristics appropriate for topical administration. Finally, this study demonstrates that Syzygium cumini seed extract can be successfully formulated into an ethosomal gel, offering a promising herbal alternative for acne management with improved dermal delivery.