Phytochemical Screening and Therapeutic Potential Evaluation from the leaves of Alangium chinense (Lour.) Harms to Validate Traditional Medicinal Knowledge

Background: Alangium chinense is a traditionally important medicinal plant among the indigenous community of Manipur, India. However, its bioactive profile has not been scientifically investigated to date. This study presents the preliminary chemical profiling of A. chinense leaves using LC-MS and GC-MS. Methods: Chemical profiling of A. chinense leaves was conducted using solvent extraction methods, followed by LC-MS and GC-MS analysis to identify and evaluate the bioactive compounds. Result: This study reveals the presence of several phytochemicals including sinapic acid, leonurine, pyridinoline, kyotorphin, goyaglycoside C, (R)-hydnocarpic acid, pentanoic acid, 5-hydroxy-2,4-di-t-butylphenyl, 2-methylhexacosane, tetracosane, nonacosane, phenol, 2,4-bis (1,1-dimethylethyl)- phosphite (3:1) and 9,12-octadecadienoic acid many of which are known for their antioxidant, anticancer, anti-inflammatory, antimicrobial, neuroprotective and antidiabetic properties. A novel compound, medicanine and several other metabolites with unknown bioactivities were also detected during the study, which highlights the need for further studies to explore their potential bioactive roles. Overall, this research highlights the potential of A. chinense as a promising candidate for prospective drug discovery, dermo-cosmetics and functional foods, while promoting conservation of ethno-medicine and biodiversity.