ACUTE TOXICITY STUDY OF A FOOD ADDITIVE COMBINATION (MONOSODIUM GLUTAMATE AND TARTRAZINE) IN ALBINO RATS

Objective: To evaluate the Acute toxicity studies of a Food Additive Combination (Monosodium Glutamate and Tartrazine) in Albino Rats. Methods: Acute toxicity study was conducted at a dose of 90 mg/kg of Monosodium glutamate and 2mg/kg of Tartrazine. Animals were grouped into 4 groups for acute studies. According to OECD guidelines observation were recorded immediately after 30 min, 1, 2, 4, 8, 24 and 48 h test administration from respectively. Results: Change in the behavior of animals were observed in the animals of acute study. Histopathology of liver, Kidney, brain and heart of sub-acute study animals in all three test groups had shown necrosis, fibrosis, inflammation and formation of vacuoles. Conclusion: Monosodium glutamate and Tartrazine alone or in combination may lead to mild/severe organ toxicities depends on its exposure or convention.