Study of the protective role of the alcoholic extract of Cordia myxa against tartrazine hepatotoxicity

The current study aims to know the protective effect of the alcoholic extract of the fruits of the plant Cordia myxa on the liver tissue in white rats treated with tartrazine. The current study included 24 laboratory rats, their weights ranged between (250-200) grams, and their ages between (11-12) weeks. The animals were divided into four groups, with six animals for each group. The first group was considered a negative control group, given water and fodder freely. The second group was dosed with the aqueous solution of tartrazine at a dose of 400) mg/kg of body weight, while the third group was dosed with the alcoholic extract of the fruits of the plant Cordia myxa at a concentration of (1000) mg/kg of body weight. The fourth group was considered a protective group and was dosed with the alcoholic extract of the fruits of Cordia myxa at a dose of 1000) mg/kg of body weight. After 3 hours, it was dosed with tartrazine. After the 30-day experimental period, the animals were anesthetized with chloroform, dissected, and liver samples were taken to prepare histological sections. The results of examining the histological sections showed histological changes in the liver tissue of the animals treated with tartrazine, caused by oxidative stress resulting from the release of free radicals into the blood. The results of examining the prepared sections showed no histological changes in the liver tissue of the animals treated with the alcoholic extract. The results of examining the liver tissue of the animals treated with the extract of the bambur plant as a preventative substance showed that they were less affected by tartrazine toxicity when compared to the samples of the rat group treated with tartrazine, as the tissue appeared closer to normal, with a normal central vein and strong regularity of the hepatic cords. We conclude that the alcoholic extract of the pomegranate fruit can be used in medical treatments as it has a preventive effect against the toxicity caused by tartrazine dye by improving the liver structure