Formulation and Evaluation of Mebendazole Loaded Microsponge for Colon Targeting

Current study aimed to design Mebendazole loaded microsponges using Eudragit S100 polymer for colon targeting. Mebendazole drug commonly used for different worm infections. Mebendazole microsponges were made utilizing the quasi-emulsion solvent diffusion process and the Eudragit S100 Prepared microsponges Mebendazole were evaluated to different evaluation parameter like FTIR, particle size, entrapment capacity, drug release study and kinetics study. Optimized Mebendazole formulation having highest entrapment capacity (88.26%) and the mean particle size 27.37, showed spongy, spherical and uniform shape. Drug-polymer interactions study confirmed by FTIR and crystallinity issues by X-ray diffraction studies. The release pattern of the optimized batch followed the Korsmeyer-Peppas model. Stability study of optimized batch was within permissible limits. Present work suggests that Mebendazole-loaded microsponges were prepared using Eudragit S100 polymer for colon targeting to increase bioavailability and reduce side effects.