Formulation, Development and Evaluation of Microsponge Based Gel of Crisaborole

The objective of present research work was to formulate microsponge gel of crisaborole drug for the treatment of atopic dermatitis. By using 32 full factorial design optimization of crisaborole microsponge gel was done and optimized microsponge was incorporated into gel and micro sponge gel of crisaborole was formulated. Spectrometric analysis of Crisaborole was done by using UV- Visible spectrophotometer and DrugExcipients compatibility study was conducted by Fourier transform infrared spectroscopy. The preliminary trial batches were formulated using the two different polymers like ethyl cellulose and Eudragit S 100. From it the micro sponge batch was selected. The 32 full factorial design was applied using Design Expert 13 software. Concentration of Ethyl cellulose (X1) and Concentration of PVA (X2) were chosen as independent variables, while % Entrapment efficiency (Y1), Particle size (nm) (Y2) was selected as dependent variables. Check point batch was prepared and evaluated for the validations of model. From this the optimized batch was selected and evaluated further for different parameters such as pH, consistency, homogeneity, %drug diffusion and % drug content. The SEM study and the particle size of the optimized batch were evaluated. Optimized microsponge was converted into microsponge gel by utilizing carbopol 934 as gelling agent and evaluated for different parameters such as colour, homogeneity, consistency, pH, viscosity, spreadability, extrudability, % drug release and % drug content. Microsponge gel was subjected to stability study under accelerated condition for one month.