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Exploring Therapeutic Potential of 1,3,4-Oxadiazole Nucleus as Anticancer Agents: A Mini-review
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Abstract:
Cancer is an uncontrolled, abnormal growth of cells and the second cause of death after
cardiovascular disease. At present, chemotherapy and related drugs have three major categories.
All three have characteristic action and toxicity levels of antitumor activity. Due to indications of
unwanted side effects, the exploration of novel and selective anticancer agents is crucially required.
Heterocyclic compounds have always played a major role in research for new drug discovery
and development. 1,3,4-oxadiazole derivatives are heterocyclic isomers having pharmacological
properties and play an important role as antiproliferative agents. The present review summarizes
anticancer activities of 1,3,4-oxadiazole derivatives against different cell lines, such as
HCT-116, MCF-7, HeLa, SMMC-7721, and A549. The results showed that 1,3,4-oxadiazole and
its derivatives have the potential to play a major role as an anticancer agent with fewer side effects.
Bentham Science Publishers Ltd.
Title: Exploring Therapeutic Potential of 1,3,4-Oxadiazole Nucleus as Anticancer
Agents: A Mini-review
Description:
Abstract:
Cancer is an uncontrolled, abnormal growth of cells and the second cause of death after
cardiovascular disease.
At present, chemotherapy and related drugs have three major categories.
All three have characteristic action and toxicity levels of antitumor activity.
Due to indications of
unwanted side effects, the exploration of novel and selective anticancer agents is crucially required.
Heterocyclic compounds have always played a major role in research for new drug discovery
and development.
1,3,4-oxadiazole derivatives are heterocyclic isomers having pharmacological
properties and play an important role as antiproliferative agents.
The present review summarizes
anticancer activities of 1,3,4-oxadiazole derivatives against different cell lines, such as
HCT-116, MCF-7, HeLa, SMMC-7721, and A549.
The results showed that 1,3,4-oxadiazole and
its derivatives have the potential to play a major role as an anticancer agent with fewer side effects.
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