(114) VACCINATION AGAINST HPV AND ITS INFLUENCE ON THE RECURRENCE OF GENITAL WARTS IN ADULT MEN UNDERGOING ABLATIVE THERAPY IN A UROLOGICAL CENTER IN LIMA DURING THE YEAR 2021

Abstract Introduction The human papillomavirus is associated with multiple pathologies, one of them genital warts, with a high prevalence in males and high rates of recurrence as well as new events. For this reason, many therapies are being studied, particularly vaccination as secondary prophylaxis has been linked to a decrease in the recurrence of genital warts. For this reason, many therapies are under constant study, particularly vaccination as secondary prophylaxis, which has been related to a decrease in the recurrence of genital warts. Objective Determine the influence of HPV vaccination on the recurrence of genital warts in adult men undergoing ablative therapy in a urological center in Lima during the year 2021To determine the influence of HPV vaccination on the recurrence of genital warts in adult men undergoing ablative therapy in a urological center in Lima during the year 2021. Methods This is a retrospective cohort study, in which the medical records of adult men who had genital warts and were treated for their ablation in a urological center in Lima during the year 2021 were evaluated. The sample size was calculated with the Openepi software, a total of 144 patients were included, 74 with complete immunization and 70 not immunized. A simple random sampling was developed. Patients who had previously received or during the follow-up period any additional treatment for HPV and patients with medical disorders requiring chronic use of medication or immunosuppression were excluded from randomization. All data were processed by the R Studio program for subsequent analysis with the chi-square test and Kaplan–Meier survival test with univariate and multivariate COX regression. This is a retrospective cohort study, in which the medical records of adult men who had genital warts and were treated for their ablation in a urological center in Lima during 2021 were evaluated. A simple random sampling was developed. Patients who had previously received or during the follow-up period any additional treatment for HPV and patients with medical disorders requiring chronic use of medication or immunosuppression were excluded from randomization. All data were processed by the R Studio program for subsequent analysis with the chi-square test and Kaplan–Meier survival test with univariate and multivariate COX regression. Results A total of 144 patients were included, 74 with complete immunization and 70 not immunized. It was found that the incidence of post-ablation warts was 47.22% (n = 68), where 31% (n = 23) were vaccinated patients and 64% (n = 45) were not vaccinated. The analysis did not show significant findings on the influence of the HPV vaccine on the recurrence of genital warts (p = 0.71). On the other hand, it is observed that vaccinated patients exhibited a lower number of subsequent wart events compared to those not vaccinated, being statistically significant with a value of P < 0.0001. (HR: 0.29, 95% CI: 0.17–0.51, p < 0.001). Conclusions HPV vaccination did not influence genital wart recurrence in adult males undergoing ablative therapy, however, vaccinated patients exhibited a lower number of subsequent wart events compared to those unvaccinated. Disclosure No.