Comparative Antiemetic Study of Fruit, Leaves and Bark Extract of Cordia Gharaf and Cordia Myxa via Dopaminergic Pathway: in-vivo Study

Vomiting, often associated with various ailments and as a side effect of treatments like chemotherapy, remains a challenging symptom to manage. This study aimed to evaluate the antiemetic properties of ethanolic extracts derived from the bark, fruit, and leaves of Cordia gharaf and Cordia myxa. Using a copper sulphate-induced chick emesis model with young chicks aged 7-10 days, we assessed the reduction in the number of retches as a measure of antiemetic efficacy. Extracts were administered at a dose of 150mg/kg, with Chlorpromazine (150mg/kg) and Domperidone (100mg/kg) serving as reference standards. Notably, the ethanolic extracts from C. gharaf bark, leaves, and C. myxa fruit demonstrated significant antiemetic effects compared to the standard groups. Phytochemical analysis revealed the presence of flavonoids and alkaloids in these extracts, suggesting their potential contribution to the observed antiemetic activity. These findings highlight the prospective role of these extracts as natural antiemetic remedies, warranting further exploration in future research endeavors.