The biochemical effects of Kola Nitida on the Liver of Lipid-Induced Wistar Rats

This study investigates the biochemical effects of Kola Nitida on the liver of Wistar rats subjected to a high lipid diet. A High lipid diet induces oxidative stress, inflammation, and pancreatic dysfunction. This study evaluated whether Kola Nitida, known for its bioactive compounds such as flavonoids, caffeine, and theobromine, could protect the liver from lipid-induced damage. The study was conducted within 6 months (April – September 2024). The effect of bioactive compounds from kola nut extracts on liver functions of Wistar rats was investigated using standard methods. Twenty Wistar rats were used for the study. They were randomly divided into five groups 1, 2, 3, control, and toxicity made up of 4 rats each. The control group received water food, Group 1 received kola nitida extract 100mg/kg body weight water food, group (B) received kola nitida extract 200mg/kg body weight water food, and Group (C) received kola nitida extract 300mg/kg body weight water food by oral administration for 14 days. The results showed that caffeine from kola nuts had effects on the liver functions of the Wistar rats. Administration of kola nitida (vera) significantly decreased aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), GGT, Total bilirubin (TB), Total protein (TP), Albumin (ALB), activities, consumption of HFD increased total bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP)activity. Body weight, organ weight, and histopathological study were significantly reduced. This study seems to suggest that consumption of HFD and reversal with kolanut (kola nitida) will significantly cause positive effects on the biological and histological liver functions of humans.