The effect of crocin on the proliferation, inflammation, drug synergism, and angiogenesis in breast cancer

Radiation, chemotherapy, and surgery are common treatments for breast cancer. These approaches, however, could only improve the odds of surviving. Using herbal medicines like crocin is now necessary to improve cancer treatment, particularly for breast cancer. According to research, crocin inhibits the growth of cancerous cells while having no effect on the development of healthy cells. By eating this substance, the side effects of cancer chemotherapy are also reduced. Thus, this review delves into the effects of crocin on breast cancer, encompassing anti-angiogenesis, drug synergism, proliferation, and inflammation. Crocin decreases the expression of CD34 in tumor tissues, leading to anti-angiogenesis. Furthermore, the anti-angiogenic effect of crocin can hinder vascular endothelial cell proliferation, migration, and tubule formation in vitro, as well as tumor cell proliferation and reduction in microvascular density in vivo. Also, crocin increases the sensitivity of PTX in breast cancer cell lines.