Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Crocin in eye diseases, a comprehensive review
View through CrossRef
Background Background: Crocin is a natural ingredient of saffron (Crocus
sativus L.) flower. Crocin has been examined for its potential to treat
various eye diseases such as glaucoma, macular dystrophies, diabetic
retinopathy, and age-related macular degeneration. Methods: This review
briefly discusses the role of crocin in different eye diseases. The
underlying pathophysiological pathways involved in the effect of crocin
on ophthalmologic diseases are also reviewed. Results: Preclinical
evidence shows the cytoprotective, antioxidative, anti-inflammatory, and
blood flow enhancing effects of crocin in retinal tissue. Crocin also
affects the retinal pathologies through activation of PI3K/Akt and
inhibition of NF-κB signaling pathways. Clinical evidence suggests that
crocin improves outcomes in patients with retinal degenerations, retinal
dystrophies, and glaucoma. Conclusion: Crocin can be used as a potential
vision supplement in healthy population and patients with eye diseases.
Title: Crocin in eye diseases, a comprehensive review
Description:
Background Background: Crocin is a natural ingredient of saffron (Crocus
sativus L.
) flower.
Crocin has been examined for its potential to treat
various eye diseases such as glaucoma, macular dystrophies, diabetic
retinopathy, and age-related macular degeneration.
Methods: This review
briefly discusses the role of crocin in different eye diseases.
The
underlying pathophysiological pathways involved in the effect of crocin
on ophthalmologic diseases are also reviewed.
Results: Preclinical
evidence shows the cytoprotective, antioxidative, anti-inflammatory, and
blood flow enhancing effects of crocin in retinal tissue.
Crocin also
affects the retinal pathologies through activation of PI3K/Akt and
inhibition of NF-κB signaling pathways.
Clinical evidence suggests that
crocin improves outcomes in patients with retinal degenerations, retinal
dystrophies, and glaucoma.
Conclusion: Crocin can be used as a potential
vision supplement in healthy population and patients with eye diseases.
Related Results
Crocin Improves the Endothelial Function Regulated by Kca3.1 Through ERK and Akt Signaling Pathways
Crocin Improves the Endothelial Function Regulated by Kca3.1 Through ERK and Akt Signaling Pathways
Background/Aims: Based on the protective effect of crocin against cardiovascular diseases, we hypothesize that crocin could improve endothelial function through activating the eNOS...
Crocin, an active constituent of Crocus sativus ameliorates cerulein induced pancreatic inflammation and oxidative stress
Crocin, an active constituent of Crocus sativus ameliorates cerulein induced pancreatic inflammation and oxidative stress
Acute pancreatitis (AP) is a disorder of the pancreas marked by profound inflammation and oxidative stress. Phytoconstituents presents an important toolbox of preventive strategies...
Antidepressant Effect of Crocin in Mice with Chronic Mild Stress
Antidepressant Effect of Crocin in Mice with Chronic Mild Stress
This study aimed to investigate the antidepressant property of crocin (Crocetin digentiobiose ester) using a chronic mild stress (CMS)-induced depression model in experimental mice...
Abstract 1621: Potent anti-cancer effect of crocin against hepatocellular carcinoma: A preclinical study
Abstract 1621: Potent anti-cancer effect of crocin against hepatocellular carcinoma: A preclinical study
Abstract
Background: This is a follow up of our study published in September issue of Hepatology and featured in October issue of Science News that documented the an...
Carotenoids composition, antioxidant and antimicrobial capacities of Crocus
sativus L. stigma
Carotenoids composition, antioxidant and antimicrobial capacities of Crocus
sativus L. stigma
Carotenoid compounds are effective free-radical scavengers because they display a singlet
oxygen-quenching property and can trap peroxyl radicals. Many extracts derived from
natura...
Effect of Saffron Extract and Crocin in Serum Metabolites of Induced Obesity Rats
Effect of Saffron Extract and Crocin in Serum Metabolites of Induced Obesity Rats
The effect of saffron extract (Crocus sativus L.) and its primary compound crocin was studied on an induced obesity rat model. Our study is aimed at investigating and comparing the...
Crocus Sativusand Its Active Compound, Crocin Inhibits the Endothelial Activation and Monocyte-Endothelial Cells Interaction in Stimulated Human Coronary Artery Endothelial Cells
Crocus Sativusand Its Active Compound, Crocin Inhibits the Endothelial Activation and Monocyte-Endothelial Cells Interaction in Stimulated Human Coronary Artery Endothelial Cells
AbstractCrocus sativus L.or saffron has been shown to have anti-atherogenic effects. However, its effects on key events in atherogenesis such as endothelial activation and monocyte...
The effect of crocin on the proliferation, inflammation, drug synergism, and angiogenesis in breast cancer
The effect of crocin on the proliferation, inflammation, drug synergism, and angiogenesis in breast cancer
Radiation, chemotherapy, and surgery are common treatments for breast cancer. These approaches, however, could only improve the odds of surviving. Using herbal medicines like croci...