Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Evolution and effectiveness of HPLC technique for rapid estimation of an antiallergenic agent bilastine
View through CrossRef
A new, simple, accurate and specific RP-HPLC stability indicating method
for determination of bilastine has been developed and validated. The
proposed method has been administrated by C18 BDS Hypersil thermo column
(4.6 x 250 mm i.d), 5 µm particle size with a combination of potassium
dihydrogen phosphate buffer pH 6.0: acetonitrile: methanol (50:25:25) as
mobile phase at wave length 220 nm. The retention time has been 3.9 min
for bilastine. Calibration plot has been linear over the concentration
range 14.4–33.6 µg/ml bilastine with LOD and LOQ of 0.04 and 0.11
µg/ml, severally. The technique has been validated for linearity,
sensitivity, accuracy, precision and robustness. Percent recoveries have
been observed near to a hundred percent with slight change. The
validated method has been applied for determination of bilastine in
Pharma-bilast(R) tablets. The technique could be appropriate for routine
evaluation at laboratories.
Title: Evolution and effectiveness of HPLC technique for rapid estimation of an antiallergenic agent bilastine
Description:
A new, simple, accurate and specific RP-HPLC stability indicating method
for determination of bilastine has been developed and validated.
The
proposed method has been administrated by C18 BDS Hypersil thermo column
(4.
6 x 250 mm i.
d), 5 µm particle size with a combination of potassium
dihydrogen phosphate buffer pH 6.
0: acetonitrile: methanol (50:25:25) as
mobile phase at wave length 220 nm.
The retention time has been 3.
9 min
for bilastine.
Calibration plot has been linear over the concentration
range 14.
4–33.
6 µg/ml bilastine with LOD and LOQ of 0.
04 and 0.
11
µg/ml, severally.
The technique has been validated for linearity,
sensitivity, accuracy, precision and robustness.
Percent recoveries have
been observed near to a hundred percent with slight change.
The
validated method has been applied for determination of bilastine in
Pharma-bilast(R) tablets.
The technique could be appropriate for routine
evaluation at laboratories.
Related Results
A Validated Stability Indicating HPTLC Method for Bilastine and Montelukast in Pharmaceutical Dosage Form
A Validated Stability Indicating HPTLC Method for Bilastine and Montelukast in Pharmaceutical Dosage Form
An accurate and precise and robust method has been described for Stability Indicating HPTLC method for development and validation for Bilastine and Montelukast in pharmaceutical do...
DEVELOPMENT AND VALIDATION OF RP-HPLC BASED ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST AND BILASTINE IN TABLET DOSAGE FORM
DEVELOPMENT AND VALIDATION OF RP-HPLC BASED ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST AND BILASTINE IN TABLET DOSAGE FORM
A new RP-HPLC method was developed for the estimation of bilastine and montelukast in tablets and it was validated as per ICH guidelines. The chromatogram for was found to be satis...
Pharmacological profile of antihistamines: focus on unwanted drug interactions
Pharmacological profile of antihistamines: focus on unwanted drug interactions
Differences between individual antihistamines are determined by such pharmacokinetic properties as the rate and completeness of absorption, half-life, the participation of hepatic ...
Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Bilastine and Montelukast in Tablet Dosage Form
Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Bilastine and Montelukast in Tablet Dosage Form
Place of Study: Department of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana.
Aim: The present study is describing about the development of a...
Photodegradation kinetics of Bilastine in tablets
Photodegradation kinetics of Bilastine in tablets
Photodegradation is the process by which a chemical substance is broken down through exposure to light, typically ultraviolet (UV) radiation. This process is significant in environ...
Efficacy of Bilastine in the Management of Urticaria- A Retrospective Study
Efficacy of Bilastine in the Management of Urticaria- A Retrospective Study
Background: Urticaria or hives is a common skin condition with a lifetime prevalence of 7.8–22.3%, a point prevalence of 0.5- 1.0%. This study focuses to determine the efficacy of ...
A highly sensitive spectrofluorimetric method for the determination of bilastine in human plasma: Application of content uniformity testing
A highly sensitive spectrofluorimetric method for the determination of bilastine in human plasma: Application of content uniformity testing
AbstractBilastine, a new second generation antihistaminic drug, has been widely used for relieving symptoms of allergic rhinitis and urticaria without a sedative effect. A simple, ...
RP-HPLC Method for Quantification of Bilastine and Monteleukast Sodium in Pharmaceutical Dosage form
RP-HPLC Method for Quantification of Bilastine and Monteleukast Sodium in Pharmaceutical Dosage form
A simple, accurate, precise and robust reverse phase high performance liquid chromatographic (RP-HPLC) method was developed and validated for the simultaneous estimation of Bilasti...