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Evolution and effectiveness of HPLC technique for rapid estimation of an antiallergenic agent bilastine
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A new, simple, accurate and specific RP-HPLC stability indicating method
for determination of bilastine has been developed and validated. The
proposed method has been administrated by C18 BDS Hypersil thermo column
(4.6 x 250 mm i.d), 5 µm particle size with a combination of potassium
dihydrogen phosphate buffer pH 6.0: acetonitrile: methanol (50:25:25) as
mobile phase at wave length 220 nm. The retention time has been 3.9 min
for bilastine. Calibration plot has been linear over the concentration
range 14.4–33.6 µg/ml bilastine with LOD and LOQ of 0.04 and 0.11
µg/ml, severally. The technique has been validated for linearity,
sensitivity, accuracy, precision and robustness. Percent recoveries have
been observed near to a hundred percent with slight change. The
validated method has been applied for determination of bilastine in
Pharma-bilast(R) tablets. The technique could be appropriate for routine
evaluation at laboratories.
Title: Evolution and effectiveness of HPLC technique for rapid estimation of an antiallergenic agent bilastine
Description:
A new, simple, accurate and specific RP-HPLC stability indicating method
for determination of bilastine has been developed and validated.
The
proposed method has been administrated by C18 BDS Hypersil thermo column
(4.
6 x 250 mm i.
d), 5 µm particle size with a combination of potassium
dihydrogen phosphate buffer pH 6.
0: acetonitrile: methanol (50:25:25) as
mobile phase at wave length 220 nm.
The retention time has been 3.
9 min
for bilastine.
Calibration plot has been linear over the concentration
range 14.
4–33.
6 µg/ml bilastine with LOD and LOQ of 0.
04 and 0.
11
µg/ml, severally.
The technique has been validated for linearity,
sensitivity, accuracy, precision and robustness.
Percent recoveries have
been observed near to a hundred percent with slight change.
The
validated method has been applied for determination of bilastine in
Pharma-bilast(R) tablets.
The technique could be appropriate for routine
evaluation at laboratories.
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