Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Kinetics of placentally transferred phenytoin and its p‐hydroxylated metabolites in newborn infants.
View through CrossRef
1 The kinetics of phenytoin and its main metabolites, unconjugated and conjugated 4‐hydroxy‐phenytoin were studied in newborn infants of epileptic mothers that were treated with phenytoin during the pregnancy. 2 In two of the infants phenytoin was eliminated by an apparent zero‐order process followed by an apparent first‐order process. In the other two infants the mode of elimination could not be characterized. 3 The decline of plasma conjugated 4‐hydroxy‐phenytoin was parallel to that of phenytoin. In contrast, the plasma concentration of unconjugated 4‐hydroxy‐phenytoin remained grossly constant during the first 3 to 4 days.
Title: Kinetics of placentally transferred phenytoin and its p‐hydroxylated metabolites in newborn infants.
Description:
1 The kinetics of phenytoin and its main metabolites, unconjugated and conjugated 4‐hydroxy‐phenytoin were studied in newborn infants of epileptic mothers that were treated with phenytoin during the pregnancy.
2 In two of the infants phenytoin was eliminated by an apparent zero‐order process followed by an apparent first‐order process.
In the other two infants the mode of elimination could not be characterized.
3 The decline of plasma conjugated 4‐hydroxy‐phenytoin was parallel to that of phenytoin.
In contrast, the plasma concentration of unconjugated 4‐hydroxy‐phenytoin remained grossly constant during the first 3 to 4 days.
Related Results
The Phenytoin Ataxia Enigma Unveiled “A Case Report’’
The Phenytoin Ataxia Enigma Unveiled “A Case Report’’
Background: Phenytoin (PHT) has been approved for the treatment of epilepsy. It belongs to the category of medications with a limited therapeutic window and requires therapeutic dr...
Long-term dynamics of pesticide metabolites in soil and aquifers
Long-term dynamics of pesticide metabolites in soil and aquifers
Groundwater is one of the most important resources for drinking water, and has to be protected from the input of persistent substances. Nevertheless, pesticides and especially thei...
Clinical Importance of Phenytoin Monitoring to Reduce Phenytoin-Related Toxicity in Saudi Patients with Epilepsy
Clinical Importance of Phenytoin Monitoring to Reduce Phenytoin-Related Toxicity in Saudi Patients with Epilepsy
Background: Phenytoin toxicity can result from overdose, dosage changes, drug interac-tions, or physiological alterations. Symptoms range from nausea and confusion to severe cases ...
ANTICONVULSANT ACTIVITY OF ETHANOLIC EXTRACT OF AEGLE MARMELOS (L.) CORRȆAALONE AND IN COMBINATION WITH PHENYTOIN BY MAXIMAL ELECTROSHOCK INDUCED SEIZURE (MES) IN ALBINO MICE.
ANTICONVULSANT ACTIVITY OF ETHANOLIC EXTRACT OF AEGLE MARMELOS (L.) CORRȆAALONE AND IN COMBINATION WITH PHENYTOIN BY MAXIMAL ELECTROSHOCK INDUCED SEIZURE (MES) IN ALBINO MICE.
Aim: To evaluate the anticonvulsant activity of ethanolic extract of Aegle marmelos (L.) correa alone and in combination with phenytoin by
maximal electroshock (MES) induced seizur...
Phenytoin Intoxication: Burden and risk factors
Phenytoin Intoxication: Burden and risk factors
OBJECTIVE: The aim of the study is to determine: 1) the frequency of patients admitted for phenytoin toxicity and their economic burden; 2) the clinical symptoms and signs of intox...
Plasmapheresis as an Adjunctive Therapy in Phenytoin Poisoning
Plasmapheresis as an Adjunctive Therapy in Phenytoin Poisoning
ABSTRACT
Phenytoin is frequently used as an anticonvulsant. Phenytoin has saturable metabolic kinetics in overdose circumstances, making therapy ...
Clinical utility of phenytoin with loading dose versus levetiracetam in hypoalbuminemic patients admitted with neurotrauma: A retrospective study at King Hussein medical center
Clinical utility of phenytoin with loading dose versus levetiracetam in hypoalbuminemic patients admitted with neurotrauma: A retrospective study at King Hussein medical center
Background and Aims: Brain-damaged patients often take phenytoin to treat seizures. Low albumin makes the medication more closely connect to proteins, changing its effect. It may b...
The effect of oral phenytoin and vitamin C therapy on enterocutaneous fistula healing
The effect of oral phenytoin and vitamin C therapy on enterocutaneous fistula healing
Introduction: Phenytoin is reported to heal the enterocutaneous fistula. Meanwhile, vitamin C is known to improve wound healing. The comparison of phenytoin and vitamin C in the tr...