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Large-scale gene functional inference through orthology
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Orthology delineation is a cornerstone of comparative genomics that offers evolutionarily-informed hypotheses on gene function by identifying “equivalent” genes in different species. The OrthoDB catalog of orthologs, www.orthodb.org [Kriventseva, et al. 2015], represents a comprehensive resource of
comparative genomics data collating available gene functional information from UniProt, InterPro, GO, OMIM, model organism phenotypes and COG functional categories, as well as providing evolutionary annotations including rates of ortholog sequence divergence, gene copy-number profiles, homology-related
sibling groups and gene architectures. These resources enable improved and extended orthology-based gene functional inference in a comparative genomics framework that incorporates the rapidly growing numbers of newly-sequenced genomes.
Title: Large-scale gene functional inference through orthology
Description:
Orthology delineation is a cornerstone of comparative genomics that offers evolutionarily-informed hypotheses on gene function by identifying “equivalent” genes in different species.
The OrthoDB catalog of orthologs, www.
orthodb.
org [Kriventseva, et al.
2015], represents a comprehensive resource of
comparative genomics data collating available gene functional information from UniProt, InterPro, GO, OMIM, model organism phenotypes and COG functional categories, as well as providing evolutionary annotations including rates of ortholog sequence divergence, gene copy-number profiles, homology-related
sibling groups and gene architectures.
These resources enable improved and extended orthology-based gene functional inference in a comparative genomics framework that incorporates the rapidly growing numbers of newly-sequenced genomes.
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