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Colchicine Reduces Lung Injury in Experimental Acute Respiratory Distress Syndrome
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Abstract
The acute respiratory distress syndrome (ARDS) is characterized by intense dysregulated inflammation leading to lung injury and respiratory failure. We studied the effects of colchicine pre-treatment on oleic acid-induced ARDS in rats. Colchicine reduced histological lung injury by 61%, reduced lung edema, and markedly improved blood oxygenation by increasing PaO2/FiO2 from 66 ± 13 mmHg (mean ± SEM) to 246 ± 45 mmHg. Lung neutrophil recruitment was reduced by colchicine with evidence for reduced neutrophils activation, as assessed by flow cytometry. This study strongly supports the clinical development of colchicine, a widely available low-cost drug, for the prevention of ARDS in conditions causing acute lung injury.
Title: Colchicine Reduces Lung Injury in Experimental Acute Respiratory Distress Syndrome
Description:
Abstract
The acute respiratory distress syndrome (ARDS) is characterized by intense dysregulated inflammation leading to lung injury and respiratory failure.
We studied the effects of colchicine pre-treatment on oleic acid-induced ARDS in rats.
Colchicine reduced histological lung injury by 61%, reduced lung edema, and markedly improved blood oxygenation by increasing PaO2/FiO2 from 66 ± 13 mmHg (mean ± SEM) to 246 ± 45 mmHg.
Lung neutrophil recruitment was reduced by colchicine with evidence for reduced neutrophils activation, as assessed by flow cytometry.
This study strongly supports the clinical development of colchicine, a widely available low-cost drug, for the prevention of ARDS in conditions causing acute lung injury.
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