Investigation of Motor End Plate Functions in Individuals with Incidentally Detected Thymoma

Purpose: Thymoma is a mediastinal tumor that is frequently associated with Myasthenia Graves (MG) and develops from thymic epithelial cells. In our study, we aimed to determine whether there is a neuromuscular transmission defect in individuals with incidentally detected thymoma and to show whether these individuals have subclinical involvement without any clinical findings. Materials and Methods: Single fiber electromyography (SFEMG) records made between March 2019 and January 2024 were examined, individuals who underwent SFEMG due to thymoma and structural ptosis were identified and detailed file record information of the patients was accessed. Individuals with any other disease or neurological complaint were excluded from the study. Asymptomatic individuals who underwent SFEMG were divided into two groups: individuals with thymoma and individuals with structural ptosis, and the demographic information and SFEMG findings of the two groups were compared with each other. Results: Maximum jitter mean, minimum jitter mean and mean consecutive difference (MCD) values were found to be significantly higher in asymptomatic individuals with incidentally detected thymoma compared to patients with structural ptosis. Discussion: Patients with thymoma may have subclinical neuromuscular transmission abnormalities even when they are asymptomatic in terms of MG. This is important for early diagnosis of MG and understanding the pathological processes in thymoma.