Advantages and Possibility of Transcription Factors FOXOs in HCC

ABSTRACT The forkhead frame O protein (forkhead box class O proteins, FOXOs) is a highly conserved family of transcription factors, consisting of four members: FOXO 1, FOXO 3, FOXO 4, and FOXO 6. The FOXOs protein family is a ubiquitously expressed transcription factor involved in the regulation of cell cycle, cell proliferation, apoptosis, autophagy, DNA repair, antioxidative stress, and many other biological activities and plays a very important role in both physiological and pathological aspects. It is noteworthy that recent studies show that FOXOs have a significant role in the occurrence and development of tumors, particularly in primary hepatocellular carcinoma (hepatocellular carcinoma, HCC), it possesses numerous advantages. In this paper, we will summarize the structural and functional characteristics of FOXOs and summarize their tumor role and advantages in HCC, to provide new ideas for HCC research and promote the generation of more favorable prevention and treatment strategies.