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Ligand-Free Ullmann-Type Arylation of Oxazolidinones by Diaryliodonium Salts
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The arylation of azaheterocycles can be considered as one of the most important processes for the preparation of various biologically active compounds. In the present work, we describe a method for the copper-catalyzed N-arylation of hindered oxazolidinones using diaryliodonium salts. The method succeeds in good to excellent yields for the arylation of 4-alkyloxazolidinones, including sterically hindered isopropyl- and tert-butyl-substituted representatives. The efficiency of the method was demonstrated for a wide range of diaryliodonium salts - symmetric and unsymmetric as well as ortho-substituted. The developed approach can provide an important contribution in the development and preparation of novel drugs and bioactive molecules containing oxazolidinone moieties.
American Chemical Society (ACS)
Title: Ligand-Free Ullmann-Type Arylation of Oxazolidinones by Diaryliodonium Salts
Description:
The arylation of azaheterocycles can be considered as one of the most important processes for the preparation of various biologically active compounds.
In the present work, we describe a method for the copper-catalyzed N-arylation of hindered oxazolidinones using diaryliodonium salts.
The method succeeds in good to excellent yields for the arylation of 4-alkyloxazolidinones, including sterically hindered isopropyl- and tert-butyl-substituted representatives.
The efficiency of the method was demonstrated for a wide range of diaryliodonium salts - symmetric and unsymmetric as well as ortho-substituted.
The developed approach can provide an important contribution in the development and preparation of novel drugs and bioactive molecules containing oxazolidinone moieties.
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