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Evaluation of Anti-Diabetic Activity of Novel Bioactive Compounds of Carthamus Tinctorius Linn
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In the present study normal and alloxan-diabetic rats were used to evaluate the hypoglyceamic activities of the Carthamus tinctorius Linn extract and isolated compounds. Extraction of Carthamus tinctorius seeds has been carried out by supercritical fluid extraction. The obtained extract was subjected to column chromatographic separation using silica gel 100-200 and 60-120 mesh.The extracts and isolated fractions were subjected to phytochemical evaluation acute toxicity study and antidiabetic activity was performed in alloxan induced diabetic Wister albino ratsas per the OECD and CPCSEA guide-lines.The SCF extracts and fractions of seeds of Carthamus tinctorius Linn were estimated by in-vivo model and showed excellent anti-diabetic activity p le 0. 001HS.The result of FBS level was significantly decreased in SCFE of Carthamus tinctorius Linn and fraction CT1 when compared with control group The SCFE of seeds of Carthamus tinctorius Linn possess significant anti-diabetic activity in both type-I and type-II diabetes mellitus.nbsp
Rajiv Gandhi University of Health Sciences
Title: Evaluation of Anti-Diabetic Activity of Novel Bioactive Compounds of Carthamus Tinctorius Linn
Description:
In the present study normal and alloxan-diabetic rats were used to evaluate the hypoglyceamic activities of the Carthamus tinctorius Linn extract and isolated compounds.
Extraction of Carthamus tinctorius seeds has been carried out by supercritical fluid extraction.
The obtained extract was subjected to column chromatographic separation using silica gel 100-200 and 60-120 mesh.
The extracts and isolated fractions were subjected to phytochemical evaluation acute toxicity study and antidiabetic activity was performed in alloxan induced diabetic Wister albino ratsas per the OECD and CPCSEA guide-lines.
The SCF extracts and fractions of seeds of Carthamus tinctorius Linn were estimated by in-vivo model and showed excellent anti-diabetic activity p le 0.
001HS.
The result of FBS level was significantly decreased in SCFE of Carthamus tinctorius Linn and fraction CT1 when compared with control group The SCFE of seeds of Carthamus tinctorius Linn possess significant anti-diabetic activity in both type-I and type-II diabetes mellitus.
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