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Enantioselective Catalytic Synthesis of N-alkylated Indoles
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During the past two decades, the interest in new methodologies for the synthesis of chiral N-functionalized indoles has grown rapidly. The review illustrates efficient applications of organocatalytic and organometallic strategies for the construction of chiral α-N-branched indoles. Both the direct functionalization of the indole core and indirect methods based on asymmetric N-alkylation of indolines, isatins and 4,7-dihydroindoles are discussed.
Title: Enantioselective Catalytic Synthesis of N-alkylated Indoles
Description:
During the past two decades, the interest in new methodologies for the synthesis of chiral N-functionalized indoles has grown rapidly.
The review illustrates efficient applications of organocatalytic and organometallic strategies for the construction of chiral α-N-branched indoles.
Both the direct functionalization of the indole core and indirect methods based on asymmetric N-alkylation of indolines, isatins and 4,7-dihydroindoles are discussed.
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