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A Review on Thiocyanation of Indoles
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Background:
The thiocyanation of indoles is a direct way for carbon-sulfur bond formation to access
3-thiocyanato-indoles. 3-thiocyanato-indoles exhibit potent biological and pharmacological activities and also
serve as building blocks to synthesize many biologically active sulfur-containing indole derivatives.
Objective:
The aim of this review is to highlight different approaches for the thiocyanation of indoles focusing on
its scope and mechanism.
Conclusion:
In this review, we have summarized various methods for the thiocyanation of indoles. Selection of
new methods for the preparation of 3-thiocyanato-indoles will be done. The mechanistic aspects and significance
of the methods are also briefly discussed.
Bentham Science Publishers Ltd.
Title: A Review on Thiocyanation of Indoles
Description:
Background:
The thiocyanation of indoles is a direct way for carbon-sulfur bond formation to access
3-thiocyanato-indoles.
3-thiocyanato-indoles exhibit potent biological and pharmacological activities and also
serve as building blocks to synthesize many biologically active sulfur-containing indole derivatives.
Objective:
The aim of this review is to highlight different approaches for the thiocyanation of indoles focusing on
its scope and mechanism.
Conclusion:
In this review, we have summarized various methods for the thiocyanation of indoles.
Selection of
new methods for the preparation of 3-thiocyanato-indoles will be done.
The mechanistic aspects and significance
of the methods are also briefly discussed.
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