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Topo IIβ Gets to Work
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DNA topoisomerases regulate conformational changes in DNA topology by catalyzing DNA strand breakage and rejoining. Topoisomerase IIβ (Topo IIβ) alters DNA conformation near gene promoters and associates with sequence-specific transcription factors and chromatin modifying and remodeling factors. Ju
et al.
now show that DNA Topo IIβ generates double-strand breaks at transcriptional promoters when these genes are activated in a signal-dependent manner. Subsequently, DNA repair enzymes are activated and there is a resultant exchange in histone composition and local chromatin structure.
B.-G. Ju, V. V. Lunyak, V. Perissi, I. Garcia-Bassets, D. W. Rose, C. K. Glass, M. G. Rosenfeld, A topoisomerase IIβ-mediated dsDNA break required for regulated transcription.
Science
312
, 1798-1802 (2006).
[Abstract]
[Full Text]
J.-F. Haince, M. Rouleau, G. G. Poirier, Gene expression needs a break to unwind before carrying on.
Science
312
, 1752-1753 (2006).
[Summary]
[Full Text]
Title: Topo IIβ Gets to Work
Description:
DNA topoisomerases regulate conformational changes in DNA topology by catalyzing DNA strand breakage and rejoining.
Topoisomerase IIβ (Topo IIβ) alters DNA conformation near gene promoters and associates with sequence-specific transcription factors and chromatin modifying and remodeling factors.
Ju
et al.
now show that DNA Topo IIβ generates double-strand breaks at transcriptional promoters when these genes are activated in a signal-dependent manner.
Subsequently, DNA repair enzymes are activated and there is a resultant exchange in histone composition and local chromatin structure.
B.
-G.
Ju, V.
V.
Lunyak, V.
Perissi, I.
Garcia-Bassets, D.
W.
Rose, C.
K.
Glass, M.
G.
Rosenfeld, A topoisomerase IIβ-mediated dsDNA break required for regulated transcription.
Science
312
, 1798-1802 (2006).
[Abstract]
[Full Text]
J.
-F.
Haince, M.
Rouleau, G.
G.
Poirier, Gene expression needs a break to unwind before carrying on.
Science
312
, 1752-1753 (2006).
[Summary]
[Full Text].
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