Oxovanadium Complex of Mebendazole: Synthesis, Spectroscopic and Physico-chemical Characterization

The greener and cost-effective synthesis of an oxovanadium complex of mebendazole is described. The synthesis involves the use of distilled water as a solvent and refluxing, providing environmentally friendly advantages, simple work-up procedures, and a short reaction time with excellent yield. Characterization included UV-Vis and FTIR spectroscopy. The UV-Vis spectra showed intra-ligand transitions at 242 and 269 nm and charge transfer bands at 310 and 380 nm, indicating the formation of oxovanadium complex of mebendazole. The FTIR spectra confirmed coordination via the nitrogen and oxygen atoms of the ligand, evidenced by shifts in C-H, C=C, and C-O stretching bands, the appearance of a new V=O band at 977.94 cm⁻¹, and an OV-N bending band at 497.65 cm⁻¹. The metal complex with the formula [VO(L)]SO₄ was deduced, where L is mebendazole.