Neuroprotective effect of Corchorus trilocularis (L.) leaves against 3-nitropropionic acid induced Huntington disease

The impact of oxidative stress on mental performance may be mitigated by Corchorus trilocularis. The purpose of this research was to show that a combination of petroleum ether, ethyl acetate and Corchorus trilocularis leaves ethanolic extract protected rat brain tissue from neurotoxicity by 3- nitropropionicacid (3 NP) induction. Three animals were given 3-NP (30 mg/kg, i.p) and then given 100, 200 and 400 mg/kg of petroleum ether, ethyl acetate of Corchorus trilocularis ethanolic extract intraperitoneally (p.o.) daily for 14 days. Significant changes were found in 3 NP-induced animal’s biochemical (raised lipid peroxidation, superoxide dismutase, reduced catalase and reduced glutathione) and neurochemical (improved acetyl cholinesterase enzyme) profiles, as well as their behaviour (hypolocomotion, muscle in coordination and memory deficit) by the end of 14th day. Corchorus trilocularis extracts in petroleum ether, ethyl acetate and ethanol (400 mg/kg) avoided behavioral, biochemical and neurochemical changes in comparison to rats given 3 NP. Both extracts, taken individually, lacked considerable action at lower doses (100 and 200 mg/kg). The findings of work favor the exercise of Corchorus trilocularis treatment as preventative medicine for the therapy of Huntington's disease, as it prevents oxidative stress and protects brain.