Exploring the Experiences and Perceptions of Young People’s Recreational Nitrous Oxide Use

_INTRODUCTION. _This exploratory study investigated the experiences and perceptions of young people who use N2O recreationally. This is the first qualitative research conducted in Australia with young people investigating this topic in detail. The aim of this study was to explore young people's perceptions, motives, and experiences of N2O use by exploring the positive and negative effects of N2O, motives for use, practices and methods, and suggested advice, to help defines targeted harm reduction messages. _METHODS. _Participants were recruited via hard copy posters, social media advertisements, and snowball sampling. Seven in-depth semi-structured interviews were conducted with young people aged between 18-25 years who had used N2O on at least ten occasions. The interview transcripts were analysed thematically. The study was completed in accordance with COREQ criteria for qualitative research. _RESULTS. _The findings identified four overarching themes about N2O use, _1) The nature of N2O use; 2) The appeal of N2O; 3) Influences on N2O use; and 4) Perception of risk and harms of N2O use._ _DISCUSSION. _The findings indicated that perception of N2O harm was low amongst the young people in this study. The discussion identified three core factors that underpin N2O consumption: _1) Social influences; 2) Other substances and 3) Accessibility._  _CONCLUSION. _Young people in the study described their experiences as being largely pleasurable. However, several identified negative impacts although harms were primarily disregarded. Exploration of N2O effects alongside other substance use highlighted how N2O is a unique substance and should be considered as such when developing harm reduction strategies.