Coagulopathy and Its Associated Factors Among Bleeding Diathesis Patients Attending at University of Gondar Specialized Referral Hospital, Northwest Ethiopia.

Abstract Background: Coagulopathy is the major cause of mortality and morbidity throughout the world. Globally, about 26 - 45% of healthy people have a history of bleeding symptoms, which may be a result of thrombocytopenia, factor deficiency, or pathological inhibitory.Objective: To assess coagulopathy and its associated factors among bleeding diathesis patients attending at University of Gondar Specialized Referral Hospital from January to May 2020.Method: A cross-sectional study was conducted on 384 study participants with bleeding diathesis recruited by using a convenient sampling technique. Socio-demographic and clinical characteristics were collected by using questioners. Then 6ml venous blood was collected with a needle and syringe method. About 3ml blood was transferred to EDTA test tube for platelet count and 2.7ml blood was transferred to a test tube containing 0.3ml of 3.2% sodium citrated anticoagulant for coagulation test. For those study participants with prolonged coagulation tests, a mixing test was done to differentiate the causes of coagulopathy whether factor deficiency or inhibitors. Blood film and stool examination were also done for malaria and intestinal parasite identification, respectively. The data were entered into EPI-Info version 3.5.3 and then transferred to SPSS version-20 for analysis. Descriptive statistics were summarized as percentages, means, and standard deviations. Bivariate and multivariate logistic regression was used to identify the associated factors, and a P-value less than 0.05 was considered as statistically significant.Results: In this study, the prevalence of coagulopathy was 253/384 (65.9%; 95% CI: 61.16, 70.64). From them, 21.3% (54/253), 51.4% (130/253), and 27.3% (69/253) had only thrombocytopenia, only prolonged coagulation test, and mixed abnormality, respectively. Among participants with prolonged coagulation time, the prevalence of factor deficiency was 21.1% (42/199). Cardiac disease (AOR = 4.80; 95% CI: 2.65, 23.1), and other chronic diseases (AOR = 8.1; 95% CI: 1.84, 35.58) were significantly associated with coagulopathy.Conclusion: Coagulopathy due to inhibitory was a public health problem. The participant with cardiac and other chronic disease was associated with coagulopathy. Therefore, mixing tests could done for all prolonged coagulation test and it could be considered as a routine laboratory test.