Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Inhibition of α‐Glycosidase by Lippia dulcis Trevir. (Verbenaceae) Preparations, Quantification of Verbascoside, and Study of Its Molecular Docking
View through CrossRef
AbstractThis study aimed to quantify verbascoside (VEB), perform molecular docking studies of VEB with the α‐glucosidase (GL) of Bacillus stearothermophilus, and evaluate the inhibition of the enzyme by L. dulcis preparations. The substrate concentration and presence of reduced glutathione were evaluated for their effect on the in vitro inhibition of the GL enzyme. Assays were also performed in the presence and absence of simulated gastric fluid. The antidiabetic fractions 2 and 3 were the most inhibited GL, but their activity were significantly decreased in the presence of gastric fluid. Chromatographic analyses confirmed the predominant presence of VEB in the samples. The samples had VEB concentrations between 49.9 and 243.5 mg/g. Simulation of the molecular docking of VEB were consistent with its GL‐inhibitory activity. It can conclude that the crude ethanol extract and fractions show inhibitory activity against the GL enzyme.
Title: Inhibition of α‐Glycosidase by Lippia dulcis Trevir. (Verbenaceae) Preparations, Quantification of Verbascoside, and Study of Its Molecular Docking
Description:
AbstractThis study aimed to quantify verbascoside (VEB), perform molecular docking studies of VEB with the α‐glucosidase (GL) of Bacillus stearothermophilus, and evaluate the inhibition of the enzyme by L.
dulcis preparations.
The substrate concentration and presence of reduced glutathione were evaluated for their effect on the in vitro inhibition of the GL enzyme.
Assays were also performed in the presence and absence of simulated gastric fluid.
The antidiabetic fractions 2 and 3 were the most inhibited GL, but their activity were significantly decreased in the presence of gastric fluid.
Chromatographic analyses confirmed the predominant presence of VEB in the samples.
The samples had VEB concentrations between 49.
9 and 243.
5 mg/g.
Simulation of the molecular docking of VEB were consistent with its GL‐inhibitory activity.
It can conclude that the crude ethanol extract and fractions show inhibitory activity against the GL enzyme.
Related Results
Verbenaceae no Parque Estadual do Biribiri, Estado de Minas Gerais, Brasil
Verbenaceae no Parque Estadual do Biribiri, Estado de Minas Gerais, Brasil
Apresentamos o tratamento florístico de Verbenaceae no Parque Estadual do Biribiri, localizado no Planalto de Diamantina, Cadeia do Espinhaço, Estado de Minas Gerais. Com extensão ...
Potential of an aqueous extract of Lippia multiflora Moldenke (Verbenaceae) in the treatment of anxiety disorders: Possible involvement of serotoninergic transmission
Potential of an aqueous extract of Lippia multiflora Moldenke (Verbenaceae) in the treatment of anxiety disorders: Possible involvement of serotoninergic transmission
Ethnopharmacological relevance: The leaves and stems of Lippia multiflora Moldenke (Verbenaceae) are used in traditional medicine to treat depression, anxiety and epilepsy. Aim of ...
Standardization of Romanian Galeopsis tetrahit Leaf Extract in Verbascoside Using a Validated UHPLC–PDA Method
Standardization of Romanian Galeopsis tetrahit Leaf Extract in Verbascoside Using a Validated UHPLC–PDA Method
Galeopsis tetrahit L. (Lamiaceae) is a traditional European medicinal species rich in phenolic compounds, among which verbascoside is a key bioactive marker with strong antioxidant...
Efeito fungitóxico do óleo essencial de Lippia gracilis sobre Alternaria spp
Efeito fungitóxico do óleo essencial de Lippia gracilis sobre Alternaria spp
fungo Alternaria alternata vem causando sérios problemas durante a exportação de frutos de mamão (Carica papaya L.). Diante desse problema é necessária a adoção de medidas de contr...
DTMol: Pocket-based Molecular Docking using Diffusion Transformers
DTMol: Pocket-based Molecular Docking using Diffusion Transformers
Abstract
In computational chemistry, molecular docking—predicting the binding structure of a small molecule ligand to a protein—is vital for understanding interacti...
Pseudofrutos de Hovenia dulcis de Minas Gerais
Pseudofrutos de Hovenia dulcis de Minas Gerais
O objetivo deste trabalho foi caracterizar pseudofrutos de Hovenia dulcis Thunb. da mesorregião do Campus das Vertentes Minas Gerais quanto aos compostos físicos, físico-químicos e...
A review on the chemistry of some species of genus Lippia (Verbenaceae family)
A review on the chemistry of some species of genus Lippia (Verbenaceae family)
Recently, focus on plant research has increased globally and a large amount of evidence has collected to show great potential of medicinal plants employed in diverse traditional sy...
The Antibacterial Activity of Lactic Acid Bacteria from Pickled Spondias dulcis (Ambarella) against Foodborne Pathogens
The Antibacterial Activity of Lactic Acid Bacteria from Pickled Spondias dulcis (Ambarella) against Foodborne Pathogens
Pickled fruits are popular condiment not only in Malaysia but in many other countries as well. During the natural pickling process, the lactic acid bacteria are known to be able to...