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Introduction to gout
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Gout is a chronic condition of monosodium urate crystal deposition. It is the most common form of inflammatory arthritis in adults, and leads to recurrent flares of severe joint damage and musculoskeletal disability. Although treatment targets are well defined, gout management is currently poor, with low levels of treatment targets achieved. The last decade has seen major advances in the understanding and treatment of gout. This handbook summarizes key scientific advances, including new insights into mechanisms of hyperuricaemia, acute gouty arthritis, and joint damage. Principles of gout diagnosis and management are discussed in detail, with practical information about use of well-established agents and also newer therapies. Gout-specific research tools are outlined to assist clinicians with interpretation of the latest scientific literature in gout. Future strategies for improved gout management are also discussed.
Title: Introduction to gout
Description:
Gout is a chronic condition of monosodium urate crystal deposition.
It is the most common form of inflammatory arthritis in adults, and leads to recurrent flares of severe joint damage and musculoskeletal disability.
Although treatment targets are well defined, gout management is currently poor, with low levels of treatment targets achieved.
The last decade has seen major advances in the understanding and treatment of gout.
This handbook summarizes key scientific advances, including new insights into mechanisms of hyperuricaemia, acute gouty arthritis, and joint damage.
Principles of gout diagnosis and management are discussed in detail, with practical information about use of well-established agents and also newer therapies.
Gout-specific research tools are outlined to assist clinicians with interpretation of the latest scientific literature in gout.
Future strategies for improved gout management are also discussed.
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Gout research tools
Gout research tools
Although most tools used in gout research are generic, there are some important gout-specific instruments. New gout classification criteria were published in 2015. Outcome measure ...
Pathophysiology of gout
Pathophysiology of gout
The clinical features of gout occur in response to monosodium urate (MSU) crystals. Gout should be considered a chronic disease of MSU crystal deposition. A number of pathophysiolo...
Treatment of acute gout
Treatment of acute gout
Acute gout is a common inflammatory arthritis in the adult population. Epidemiological evidence suggests that the prevalence of gout is steadily on the rise due to longevity, coexi...
Epidemiology of gout
Epidemiology of gout
Gout is the most prevalent inflammatory arthritis in men. Data from epidemiological studies conducted in several countries suggest that the prevalence and incidence of gout have ri...
Imaging in gout
Imaging in gout
Identification of monosodium urate (MSU) crystals is the gold standard for gout diagnosis. Serum urate is an important test for both gout diagnosis and effective management. For al...
Laboratory testing in gout diagnosis and management
Laboratory testing in gout diagnosis and management
Gout typically presents as recurrent flares of acute self-limiting arthritis. The acute gout flare is characterized by severe joint inflammation. In the presence of prolonged untre...
Principles of gout management
Principles of gout management
The main goal of therapy is to achieve ‘remission’—the absence of gout attacks and tophi. A sustained reduction in serum urate is critical to the long-term management of gout and w...